Cargando…

Decreased serum MMP-9 levels in patients with nontraumatic osteonecrosis of the femoral head

BACKGROUND: Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) are involved in the pathological mechanism of osteonecrosis of the femoral head (ONFH). This study aimed to investigate the relationship of serum MMP-9, TIMP-1, and the MMP-9/TIMP-1 ratio with diseas...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Guopeng, Ji, Fengxuan, Guo, Wenchao, Wei, Biaofang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053116/
https://www.ncbi.nlm.nih.gov/pubmed/36991363
http://dx.doi.org/10.1186/s12891-023-06342-9
_version_ 1785015335560151040
author Li, Guopeng
Ji, Fengxuan
Guo, Wenchao
Wei, Biaofang
author_facet Li, Guopeng
Ji, Fengxuan
Guo, Wenchao
Wei, Biaofang
author_sort Li, Guopeng
collection PubMed
description BACKGROUND: Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) are involved in the pathological mechanism of osteonecrosis of the femoral head (ONFH). This study aimed to investigate the relationship of serum MMP-9, TIMP-1, and the MMP-9/TIMP-1 ratio with disease severity in patients with nontraumatic ONFH. METHODS: Serum levels of MMP-9 and TIMP-1 among 102 nontraumatic ONFH patients and 96 healthy individuals were determined by enzyme-linked immunosorbent assay (ELISA). Imaging severity was determined using the FICAT classification system. The Harris hip score (HHS) and visual analogue scale (VAS) were used to evaluate clinical progress. The correlations of serum MMP-9 and TIMP-1 levels with imaging severity and clinical progress was evaluated statistically. The diagnostic value of MMP-9 for NONFH disease severity was evaluated by examining receiver operating characteristic (ROC) curves. RESULTS: The serum MMP-9 levels and the MMP-9/TIMP-1 ratio were significantly increased in patients with ONFH compared to normal controls, and TIMP-1 levels did not differ between the two groups. Serum MMP-9 levels and the MMP-9/TIMP-1 ratio were positively correlated with FICAT stage and VAS and were negatively correlated with the HHS score. The ROC curve results indicated that MMP-9 could be used as a potential marker of nontraumatic ONFH imaging progression. CONCLUSIONS: We hypothesize that increased MMP-9 expression and an imbalance in the MMP-9/TIMP-1 ratio play a role in the development of ONFH and are correlate with the severity of ONFH. The determination of MMP-9 can be a useful tool to assess the severity of the disease in patients with nontraumatic ONFH.
format Online
Article
Text
id pubmed-10053116
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-100531162023-03-30 Decreased serum MMP-9 levels in patients with nontraumatic osteonecrosis of the femoral head Li, Guopeng Ji, Fengxuan Guo, Wenchao Wei, Biaofang BMC Musculoskelet Disord Research BACKGROUND: Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) are involved in the pathological mechanism of osteonecrosis of the femoral head (ONFH). This study aimed to investigate the relationship of serum MMP-9, TIMP-1, and the MMP-9/TIMP-1 ratio with disease severity in patients with nontraumatic ONFH. METHODS: Serum levels of MMP-9 and TIMP-1 among 102 nontraumatic ONFH patients and 96 healthy individuals were determined by enzyme-linked immunosorbent assay (ELISA). Imaging severity was determined using the FICAT classification system. The Harris hip score (HHS) and visual analogue scale (VAS) were used to evaluate clinical progress. The correlations of serum MMP-9 and TIMP-1 levels with imaging severity and clinical progress was evaluated statistically. The diagnostic value of MMP-9 for NONFH disease severity was evaluated by examining receiver operating characteristic (ROC) curves. RESULTS: The serum MMP-9 levels and the MMP-9/TIMP-1 ratio were significantly increased in patients with ONFH compared to normal controls, and TIMP-1 levels did not differ between the two groups. Serum MMP-9 levels and the MMP-9/TIMP-1 ratio were positively correlated with FICAT stage and VAS and were negatively correlated with the HHS score. The ROC curve results indicated that MMP-9 could be used as a potential marker of nontraumatic ONFH imaging progression. CONCLUSIONS: We hypothesize that increased MMP-9 expression and an imbalance in the MMP-9/TIMP-1 ratio play a role in the development of ONFH and are correlate with the severity of ONFH. The determination of MMP-9 can be a useful tool to assess the severity of the disease in patients with nontraumatic ONFH. BioMed Central 2023-03-29 /pmc/articles/PMC10053116/ /pubmed/36991363 http://dx.doi.org/10.1186/s12891-023-06342-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Li, Guopeng
Ji, Fengxuan
Guo, Wenchao
Wei, Biaofang
Decreased serum MMP-9 levels in patients with nontraumatic osteonecrosis of the femoral head
title Decreased serum MMP-9 levels in patients with nontraumatic osteonecrosis of the femoral head
title_full Decreased serum MMP-9 levels in patients with nontraumatic osteonecrosis of the femoral head
title_fullStr Decreased serum MMP-9 levels in patients with nontraumatic osteonecrosis of the femoral head
title_full_unstemmed Decreased serum MMP-9 levels in patients with nontraumatic osteonecrosis of the femoral head
title_short Decreased serum MMP-9 levels in patients with nontraumatic osteonecrosis of the femoral head
title_sort decreased serum mmp-9 levels in patients with nontraumatic osteonecrosis of the femoral head
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053116/
https://www.ncbi.nlm.nih.gov/pubmed/36991363
http://dx.doi.org/10.1186/s12891-023-06342-9
work_keys_str_mv AT liguopeng decreasedserummmp9levelsinpatientswithnontraumaticosteonecrosisofthefemoralhead
AT jifengxuan decreasedserummmp9levelsinpatientswithnontraumaticosteonecrosisofthefemoralhead
AT guowenchao decreasedserummmp9levelsinpatientswithnontraumaticosteonecrosisofthefemoralhead
AT weibiaofang decreasedserummmp9levelsinpatientswithnontraumaticosteonecrosisofthefemoralhead