CRISPR screens identify gene targets at breast cancer risk loci

BACKGROUND: Genome-wide association studies (GWAS) have identified > 200 loci associated with breast cancer risk. The majority of candidate causal variants are in non-coding regions and likely modulate cancer risk by regulating gene expression. However, pinpointing the exact target of the associa...

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Detalles Bibliográficos
Autores principales: Tuano, Natasha K., Beesley, Jonathan, Manning, Murray, Shi, Wei, Perlaza-Jimenez, Laura, Malaver-Ortega, Luis F., Paynter, Jacob M., Black, Debra, Civitarese, Andrew, McCue, Karen, Hatzipantelis, Aaron, Hillman, Kristine, Kaufmann, Susanne, Sivakumaran, Haran, Polo, Jose M., Reddel, Roger R., Band, Vimla, French, Juliet D., Edwards, Stacey L., Powell, David R., Chenevix-Trench, Georgia, Rosenbluh, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053147/
https://www.ncbi.nlm.nih.gov/pubmed/36991492
http://dx.doi.org/10.1186/s13059-023-02898-w

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