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Executive Function and Working Memory Deficits in Females with Fragile X Premutation

The Fragile X premutation is a genetic instability of the FMR1 gene caused by 55–199 recurrences of the CGG sequence, whereas there are only 7–54 repeats of the CGG sequence in the normal condition. While males with the premutation of Fragile X were found to have difficulties in executive functions...

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Autores principales: Segal, Osnat, Kowal, Tamar, Banet-Levi, Yonit, Gabis, Lidia V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053193/
https://www.ncbi.nlm.nih.gov/pubmed/36983968
http://dx.doi.org/10.3390/life13030813
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author Segal, Osnat
Kowal, Tamar
Banet-Levi, Yonit
Gabis, Lidia V.
author_facet Segal, Osnat
Kowal, Tamar
Banet-Levi, Yonit
Gabis, Lidia V.
author_sort Segal, Osnat
collection PubMed
description The Fragile X premutation is a genetic instability of the FMR1 gene caused by 55–199 recurrences of the CGG sequence, whereas there are only 7–54 repeats of the CGG sequence in the normal condition. While males with the premutation of Fragile X were found to have difficulties in executive functions and working memory, little data have been collected on females. This study is among the first to address executive functions and phonological memory in females with the Fragile X premutation. Twenty-three female carriers aged 20–55 years and twelve non carrier females matched in age and levels of education (in years) participated in this study. Executive functions and phonological memory were assessed using the self-report questionnaire The Behavior Rating Inventory of Executive Function (BRIEF) and behavioral measures (nonword repetitions, forward and backward digit span). Females who were carriers of the premutation of the FMR1 gene reported less efficient executive functions in the BRIEF questionnaire compared to the control group. In addition, a relationship was found between the number of repetitions on the CGG sequence of nucleotides, nonword repetitions, and forward digit span. The findings suggest that the premutation of Fragile X in females affects their performance of executive functions and may have impact on everyday functioning.
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spelling pubmed-100531932023-03-30 Executive Function and Working Memory Deficits in Females with Fragile X Premutation Segal, Osnat Kowal, Tamar Banet-Levi, Yonit Gabis, Lidia V. Life (Basel) Article The Fragile X premutation is a genetic instability of the FMR1 gene caused by 55–199 recurrences of the CGG sequence, whereas there are only 7–54 repeats of the CGG sequence in the normal condition. While males with the premutation of Fragile X were found to have difficulties in executive functions and working memory, little data have been collected on females. This study is among the first to address executive functions and phonological memory in females with the Fragile X premutation. Twenty-three female carriers aged 20–55 years and twelve non carrier females matched in age and levels of education (in years) participated in this study. Executive functions and phonological memory were assessed using the self-report questionnaire The Behavior Rating Inventory of Executive Function (BRIEF) and behavioral measures (nonword repetitions, forward and backward digit span). Females who were carriers of the premutation of the FMR1 gene reported less efficient executive functions in the BRIEF questionnaire compared to the control group. In addition, a relationship was found between the number of repetitions on the CGG sequence of nucleotides, nonword repetitions, and forward digit span. The findings suggest that the premutation of Fragile X in females affects their performance of executive functions and may have impact on everyday functioning. MDPI 2023-03-17 /pmc/articles/PMC10053193/ /pubmed/36983968 http://dx.doi.org/10.3390/life13030813 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Segal, Osnat
Kowal, Tamar
Banet-Levi, Yonit
Gabis, Lidia V.
Executive Function and Working Memory Deficits in Females with Fragile X Premutation
title Executive Function and Working Memory Deficits in Females with Fragile X Premutation
title_full Executive Function and Working Memory Deficits in Females with Fragile X Premutation
title_fullStr Executive Function and Working Memory Deficits in Females with Fragile X Premutation
title_full_unstemmed Executive Function and Working Memory Deficits in Females with Fragile X Premutation
title_short Executive Function and Working Memory Deficits in Females with Fragile X Premutation
title_sort executive function and working memory deficits in females with fragile x premutation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053193/
https://www.ncbi.nlm.nih.gov/pubmed/36983968
http://dx.doi.org/10.3390/life13030813
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