Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions

Bisphenol A (BPA) is one of the so-called endocrine disrupting chemicals (EDCs) and is thought to be involved in the pathogenesis of different morbid conditions: immune-mediated disorders, type-2 diabetes mellitus, cardiovascular diseases, and cancer. The purpose of this review is to analyze the mec...

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Autores principales: Della Rocca, Ylenia, Traini, Enrico Matteo, Diomede, Francesca, Fonticoli, Luigia, Trubiani, Oriana, Paganelli, Alessia, Pizzicannella, Jacopo, Marconi, Guya Diletta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053246/
https://www.ncbi.nlm.nih.gov/pubmed/36986769
http://dx.doi.org/10.3390/pharmaceutics15030908
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author Della Rocca, Ylenia
Traini, Enrico Matteo
Diomede, Francesca
Fonticoli, Luigia
Trubiani, Oriana
Paganelli, Alessia
Pizzicannella, Jacopo
Marconi, Guya Diletta
author_facet Della Rocca, Ylenia
Traini, Enrico Matteo
Diomede, Francesca
Fonticoli, Luigia
Trubiani, Oriana
Paganelli, Alessia
Pizzicannella, Jacopo
Marconi, Guya Diletta
author_sort Della Rocca, Ylenia
collection PubMed
description Bisphenol A (BPA) is one of the so-called endocrine disrupting chemicals (EDCs) and is thought to be involved in the pathogenesis of different morbid conditions: immune-mediated disorders, type-2 diabetes mellitus, cardiovascular diseases, and cancer. The purpose of this review is to analyze the mechanism of action of bisphenol A, with a special focus on mesenchymal stromal/stem cells (MSCs) and adipogenesis. Its uses will be assessed in various fields: dental, orthopedic, and industrial. The different pathological or physiological conditions altered by BPA and the related molecular pathways will be taken into consideration.
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spelling pubmed-100532462023-03-30 Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions Della Rocca, Ylenia Traini, Enrico Matteo Diomede, Francesca Fonticoli, Luigia Trubiani, Oriana Paganelli, Alessia Pizzicannella, Jacopo Marconi, Guya Diletta Pharmaceutics Review Bisphenol A (BPA) is one of the so-called endocrine disrupting chemicals (EDCs) and is thought to be involved in the pathogenesis of different morbid conditions: immune-mediated disorders, type-2 diabetes mellitus, cardiovascular diseases, and cancer. The purpose of this review is to analyze the mechanism of action of bisphenol A, with a special focus on mesenchymal stromal/stem cells (MSCs) and adipogenesis. Its uses will be assessed in various fields: dental, orthopedic, and industrial. The different pathological or physiological conditions altered by BPA and the related molecular pathways will be taken into consideration. MDPI 2023-03-10 /pmc/articles/PMC10053246/ /pubmed/36986769 http://dx.doi.org/10.3390/pharmaceutics15030908 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Della Rocca, Ylenia
Traini, Enrico Matteo
Diomede, Francesca
Fonticoli, Luigia
Trubiani, Oriana
Paganelli, Alessia
Pizzicannella, Jacopo
Marconi, Guya Diletta
Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions
title Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions
title_full Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions
title_fullStr Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions
title_full_unstemmed Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions
title_short Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions
title_sort current evidence on bisphenol a exposure and the molecular mechanism involved in related pathological conditions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053246/
https://www.ncbi.nlm.nih.gov/pubmed/36986769
http://dx.doi.org/10.3390/pharmaceutics15030908
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