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Mean corpuscular haemoglobin concentration and outcomes in heart failure with preserved ejection fraction

AIMS: This study aims to evaluate the prognostic value of mean corpuscular haemoglobin concentration (MCHC) on clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF). METHODS AND RESULTS: We analysed HFpEF participants from the Americas in the Treatment of Preserve...

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Autores principales: Choy, Manting, Zhen, Zhe, Dong, Bin, Chen, Cong, Dong, Yugang, Liu, Chen, Liang, Weihao, Xue, Ruicong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053270/
https://www.ncbi.nlm.nih.gov/pubmed/36695165
http://dx.doi.org/10.1002/ehf2.14225
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author Choy, Manting
Zhen, Zhe
Dong, Bin
Chen, Cong
Dong, Yugang
Liu, Chen
Liang, Weihao
Xue, Ruicong
author_facet Choy, Manting
Zhen, Zhe
Dong, Bin
Chen, Cong
Dong, Yugang
Liu, Chen
Liang, Weihao
Xue, Ruicong
author_sort Choy, Manting
collection PubMed
description AIMS: This study aims to evaluate the prognostic value of mean corpuscular haemoglobin concentration (MCHC) on clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF). METHODS AND RESULTS: We analysed HFpEF participants from the Americas in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial with available baseline data (n = 1747). Patients were grouped into hypochromia or non‐hypochromia group according to a MCHC cut‐off level of 330 g/L. Cox proportional hazard model was used to explore the prognostic value of hypochromia on the long‐term clinical outcomes (the primary endpoint [composite of cardiovascular mortality, HF hospitalization and aborted cardiac arrest], any‐cause and HF hospitalization, all‐cause and cardiovascular mortality). Patients were further stratified according to baseline estimated glomerular filtration rate (eGFR) to explore the impact of renal dysfunction on the prognostic value of hypochromia. Baseline hypochromia was prevalent (n = 662, 37.9%) and strongly associated with worse clinical outcomes. In patients with worse renal function (eGFR < 60 mL/min per 1.73 m(2)), hypochromia was independently associated with primary endpoint (hazard ratio [HR], 1.56; 95% confidence interval [CI], 1.23–1.98; P < 0.001), any‐cause hospitalization (HR, 1.43; 95% CI, 1.20–1.71, P < 0.001) and HF hospitalization (HR, 1.40; 95% CI, 1.07–1.84; P = 0.015), whereas no significant association between hypochromia and these outcomes was found in patients with better renal function. CONCLUSIONS: Among HFpEF patients, hypochromia (i.e. MCHC ≤ 330 g/L) is independently associated with adverse clinical outcomes, especially when in the presence of co‐morbidity renal dysfunction.
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spelling pubmed-100532702023-03-30 Mean corpuscular haemoglobin concentration and outcomes in heart failure with preserved ejection fraction Choy, Manting Zhen, Zhe Dong, Bin Chen, Cong Dong, Yugang Liu, Chen Liang, Weihao Xue, Ruicong ESC Heart Fail Original Articles AIMS: This study aims to evaluate the prognostic value of mean corpuscular haemoglobin concentration (MCHC) on clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF). METHODS AND RESULTS: We analysed HFpEF participants from the Americas in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial with available baseline data (n = 1747). Patients were grouped into hypochromia or non‐hypochromia group according to a MCHC cut‐off level of 330 g/L. Cox proportional hazard model was used to explore the prognostic value of hypochromia on the long‐term clinical outcomes (the primary endpoint [composite of cardiovascular mortality, HF hospitalization and aborted cardiac arrest], any‐cause and HF hospitalization, all‐cause and cardiovascular mortality). Patients were further stratified according to baseline estimated glomerular filtration rate (eGFR) to explore the impact of renal dysfunction on the prognostic value of hypochromia. Baseline hypochromia was prevalent (n = 662, 37.9%) and strongly associated with worse clinical outcomes. In patients with worse renal function (eGFR < 60 mL/min per 1.73 m(2)), hypochromia was independently associated with primary endpoint (hazard ratio [HR], 1.56; 95% confidence interval [CI], 1.23–1.98; P < 0.001), any‐cause hospitalization (HR, 1.43; 95% CI, 1.20–1.71, P < 0.001) and HF hospitalization (HR, 1.40; 95% CI, 1.07–1.84; P = 0.015), whereas no significant association between hypochromia and these outcomes was found in patients with better renal function. CONCLUSIONS: Among HFpEF patients, hypochromia (i.e. MCHC ≤ 330 g/L) is independently associated with adverse clinical outcomes, especially when in the presence of co‐morbidity renal dysfunction. John Wiley and Sons Inc. 2023-01-25 /pmc/articles/PMC10053270/ /pubmed/36695165 http://dx.doi.org/10.1002/ehf2.14225 Text en © 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Choy, Manting
Zhen, Zhe
Dong, Bin
Chen, Cong
Dong, Yugang
Liu, Chen
Liang, Weihao
Xue, Ruicong
Mean corpuscular haemoglobin concentration and outcomes in heart failure with preserved ejection fraction
title Mean corpuscular haemoglobin concentration and outcomes in heart failure with preserved ejection fraction
title_full Mean corpuscular haemoglobin concentration and outcomes in heart failure with preserved ejection fraction
title_fullStr Mean corpuscular haemoglobin concentration and outcomes in heart failure with preserved ejection fraction
title_full_unstemmed Mean corpuscular haemoglobin concentration and outcomes in heart failure with preserved ejection fraction
title_short Mean corpuscular haemoglobin concentration and outcomes in heart failure with preserved ejection fraction
title_sort mean corpuscular haemoglobin concentration and outcomes in heart failure with preserved ejection fraction
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053270/
https://www.ncbi.nlm.nih.gov/pubmed/36695165
http://dx.doi.org/10.1002/ehf2.14225
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