ACAT1/SOAT1 Blockade Suppresses LPS-Mediated Neuroinflammation by Modulating the Fate of Toll-like Receptor 4 in Microglia

Cholesterol is stored as cholesteryl esters by the enzymes acyl-CoA:cholesterol acyltransferases/sterol O:acyltransferases (ACATs/SOATs). ACAT1 blockade (A1B) ameliorates the pro-inflammatory responses of macrophages to lipopolysaccharides (LPS) and cholesterol loading. However, the mediators involv...

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Detalles Bibliográficos
Autores principales: Li, Haibo, Huynh, Thao N., Duong, Michael Tran, Gow, James G., Chang, Catherine C. Y., Chang, Ta Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053317/
https://www.ncbi.nlm.nih.gov/pubmed/36982689
http://dx.doi.org/10.3390/ijms24065616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053317/
https://www.ncbi.nlm.nih.gov/pubmed/36982689
http://dx.doi.org/10.3390/ijms24065616

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