NF-κB Activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer

BACKGROUND: Adenoma-adenocarcinoma transition is a key feature of colorectal cancer (CRC) occurrence and is closely regulated by tumor-associated macrophages (TAMs) and CD8(+) T cells. Here, we investigated the effect of the NF-κB activator 1 (Act1) downregulation of macrophages in the adenoma-adeno...

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Detalles Bibliográficos
Autores principales: Wang, Shunyi, Kuai, Yihe, Lin, Simin, Li, Li, Gu, Quliang, Zhang, Xiaohan, Li, Xiaoming, He, Yajun, Chen, Sishuo, Xia, Xiaoru, Ruan, Zhang, Lin, Caixia, Ding, Yi, Zhang, Qianqian, Qi, Cuiling, Li, Jiangchao, He, Xiaodong, Pathak, Janak L., Zhou, Weijie, Liu, Side, Wang, Lijing, Zheng, Lingyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053426/
https://www.ncbi.nlm.nih.gov/pubmed/36978108
http://dx.doi.org/10.1186/s12916-023-02791-0

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