Crystal structures of dimeric and heptameric mtHsp60 reveal the mechanism of chaperonin inactivation

Mitochondrial Hsp60 (mtHsp60) plays a crucial role in maintaining the proper folding of proteins in the mitochondria. mtHsp60 self-assembles into a ring-shaped heptamer, which can further form a double-ring tetradecamer in the presence of ATP and mtHsp10. However, mtHsp60 tends to dissociate in vitr...

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Detalles Bibliográficos
Autores principales: Lai, Meng-Cheng, Cheng, Hao-Yu, Lew, Sin-Hong, Chen, Yu-An, Yu, Chien-Hung, Lin, Han-You, Lin, Shih-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053435/
https://www.ncbi.nlm.nih.gov/pubmed/36973006
http://dx.doi.org/10.26508/lsa.202201753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053435/
https://www.ncbi.nlm.nih.gov/pubmed/36973006
http://dx.doi.org/10.26508/lsa.202201753

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