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Efficacy of nasal irrigation and oral rinse with sodium bicarbonate solution on virus clearance for COVID-19 patients

BACKGROUND: Recent studies have shown that the infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is reduced under alkaline conditions. The purpose of this study is to assess the effect of nasal irrigation and oral rinse with sodium bicarbonate solution on virus clearance am...

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Autores principales: Wang, Tairong, Zhang, Yue, Zhang, Rong, Mao, Ye, Yan, Junhai, Long, Yiwen, Chen, Qiaofeng, Li, Xiaojing, Wang, Huixiang, Huang, Shuai, Zhu, Chao, Teng, Bin, Wang, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053493/
https://www.ncbi.nlm.nih.gov/pubmed/37006571
http://dx.doi.org/10.3389/fpubh.2023.1145669
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author Wang, Tairong
Zhang, Yue
Zhang, Rong
Mao, Ye
Yan, Junhai
Long, Yiwen
Chen, Qiaofeng
Li, Xiaojing
Wang, Huixiang
Huang, Shuai
Zhu, Chao
Teng, Bin
Wang, Xu
author_facet Wang, Tairong
Zhang, Yue
Zhang, Rong
Mao, Ye
Yan, Junhai
Long, Yiwen
Chen, Qiaofeng
Li, Xiaojing
Wang, Huixiang
Huang, Shuai
Zhu, Chao
Teng, Bin
Wang, Xu
author_sort Wang, Tairong
collection PubMed
description BACKGROUND: Recent studies have shown that the infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is reduced under alkaline conditions. The purpose of this study is to assess the effect of nasal irrigation and oral rinse with sodium bicarbonate solution on virus clearance among COVID-19 patients. MATERIALS AND METHODS: COVID-19 patients were recruited and randomly divided into two group, i.e., the experimental group and the control group. The experimental group received regular care plus nasal irrigation and oral rinse with 5% sodium bicarbonate solution, while the control group only received regular care. Nasopharyngeal and oropharyngeal swab samples were collected daily for reverse transcription-polymerase chain reaction (RT-PCR) assays. The negative conversion time and hospitalization time of the patients were recorded, and the results were statistically analyzed. RESULTS: A total of 55 COVID-19 patients with mild or moderate symptoms were included in our study. There was no significant difference in gender, age and health status between the two groups. The average negative conversion time was 1.63 days after treatment with sodium bicarbonate, and the average hospitalization time of the control group and the experimental group were 12.53 and 7.7 days, respectively. CONCLUSIONS: Nasal irrigation and oral rinse with 5% sodium bicarbonate solution is effective in virus clearance for COVID-19 patients.
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spelling pubmed-100534932023-03-30 Efficacy of nasal irrigation and oral rinse with sodium bicarbonate solution on virus clearance for COVID-19 patients Wang, Tairong Zhang, Yue Zhang, Rong Mao, Ye Yan, Junhai Long, Yiwen Chen, Qiaofeng Li, Xiaojing Wang, Huixiang Huang, Shuai Zhu, Chao Teng, Bin Wang, Xu Front Public Health Public Health BACKGROUND: Recent studies have shown that the infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is reduced under alkaline conditions. The purpose of this study is to assess the effect of nasal irrigation and oral rinse with sodium bicarbonate solution on virus clearance among COVID-19 patients. MATERIALS AND METHODS: COVID-19 patients were recruited and randomly divided into two group, i.e., the experimental group and the control group. The experimental group received regular care plus nasal irrigation and oral rinse with 5% sodium bicarbonate solution, while the control group only received regular care. Nasopharyngeal and oropharyngeal swab samples were collected daily for reverse transcription-polymerase chain reaction (RT-PCR) assays. The negative conversion time and hospitalization time of the patients were recorded, and the results were statistically analyzed. RESULTS: A total of 55 COVID-19 patients with mild or moderate symptoms were included in our study. There was no significant difference in gender, age and health status between the two groups. The average negative conversion time was 1.63 days after treatment with sodium bicarbonate, and the average hospitalization time of the control group and the experimental group were 12.53 and 7.7 days, respectively. CONCLUSIONS: Nasal irrigation and oral rinse with 5% sodium bicarbonate solution is effective in virus clearance for COVID-19 patients. Frontiers Media S.A. 2023-03-15 /pmc/articles/PMC10053493/ /pubmed/37006571 http://dx.doi.org/10.3389/fpubh.2023.1145669 Text en Copyright © 2023 Wang, Zhang, Zhang, Mao, Yan, Long, Chen, Li, Wang, Huang, Zhu, Teng and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Wang, Tairong
Zhang, Yue
Zhang, Rong
Mao, Ye
Yan, Junhai
Long, Yiwen
Chen, Qiaofeng
Li, Xiaojing
Wang, Huixiang
Huang, Shuai
Zhu, Chao
Teng, Bin
Wang, Xu
Efficacy of nasal irrigation and oral rinse with sodium bicarbonate solution on virus clearance for COVID-19 patients
title Efficacy of nasal irrigation and oral rinse with sodium bicarbonate solution on virus clearance for COVID-19 patients
title_full Efficacy of nasal irrigation and oral rinse with sodium bicarbonate solution on virus clearance for COVID-19 patients
title_fullStr Efficacy of nasal irrigation and oral rinse with sodium bicarbonate solution on virus clearance for COVID-19 patients
title_full_unstemmed Efficacy of nasal irrigation and oral rinse with sodium bicarbonate solution on virus clearance for COVID-19 patients
title_short Efficacy of nasal irrigation and oral rinse with sodium bicarbonate solution on virus clearance for COVID-19 patients
title_sort efficacy of nasal irrigation and oral rinse with sodium bicarbonate solution on virus clearance for covid-19 patients
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053493/
https://www.ncbi.nlm.nih.gov/pubmed/37006571
http://dx.doi.org/10.3389/fpubh.2023.1145669
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