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New Approaches on the Anti-Inflammatory and Cardioprotective Properties of Taraxacum officinale Tincture

The present research investigated the in vivo anti-inflammatory and cardioprotective activities, as well as the antioxidant potential of Taraxacum officinale tincture (TOT), in relation to the polyphenolic composition. Chromatographic and spectrophotometric techniques were used to determine the poly...

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Autores principales: Epure, Alexandra, Pârvu, Alina E., Vlase, Laurian, Benedec, Daniela, Hanganu, Daniela, Oniga, Ovidiu, Vlase, Ana-Maria, Ielciu, Irina, Toiu, Anca, Oniga, Ilioara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053582/
https://www.ncbi.nlm.nih.gov/pubmed/36986458
http://dx.doi.org/10.3390/ph16030358
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author Epure, Alexandra
Pârvu, Alina E.
Vlase, Laurian
Benedec, Daniela
Hanganu, Daniela
Oniga, Ovidiu
Vlase, Ana-Maria
Ielciu, Irina
Toiu, Anca
Oniga, Ilioara
author_facet Epure, Alexandra
Pârvu, Alina E.
Vlase, Laurian
Benedec, Daniela
Hanganu, Daniela
Oniga, Ovidiu
Vlase, Ana-Maria
Ielciu, Irina
Toiu, Anca
Oniga, Ilioara
author_sort Epure, Alexandra
collection PubMed
description The present research investigated the in vivo anti-inflammatory and cardioprotective activities, as well as the antioxidant potential of Taraxacum officinale tincture (TOT), in relation to the polyphenolic composition. Chromatographic and spectrophotometric techniques were used to determine the polyphenolic profile of TOT and the antioxidant activity was preliminarily assessed in vitro by DPPH• and FRAP spectrophotometric methods. The in vivo anti-inflammatory and cardioprotective activities were studied in rat turpentine-induced inflammation and in rat isoprenaline-induced myocardial infarction (MI) models. The main polyphenolic compound identified in TOT was cichoric acid. The oxidative stress determinations showed the capacity of the dandelion tincture not only to decrease the total oxidative stress (TOS), the oxidative stress index (OSI), and the total antioxidant capacity (TAC), but also the malondialdehide (MDA), thiols (SH), and nitrites/nitrates (NOx) levels both in inflammation and MI models. In addition, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatin kinase-MB (CK-MB), and nuclear factor kappa B (NF-κB) parameters were decreased by the administration of the tincture. The results show that T. officinale could be considered a valuable source of natural compounds with important benefits in pathologies linked to oxidative stress.
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spelling pubmed-100535822023-03-30 New Approaches on the Anti-Inflammatory and Cardioprotective Properties of Taraxacum officinale Tincture Epure, Alexandra Pârvu, Alina E. Vlase, Laurian Benedec, Daniela Hanganu, Daniela Oniga, Ovidiu Vlase, Ana-Maria Ielciu, Irina Toiu, Anca Oniga, Ilioara Pharmaceuticals (Basel) Article The present research investigated the in vivo anti-inflammatory and cardioprotective activities, as well as the antioxidant potential of Taraxacum officinale tincture (TOT), in relation to the polyphenolic composition. Chromatographic and spectrophotometric techniques were used to determine the polyphenolic profile of TOT and the antioxidant activity was preliminarily assessed in vitro by DPPH• and FRAP spectrophotometric methods. The in vivo anti-inflammatory and cardioprotective activities were studied in rat turpentine-induced inflammation and in rat isoprenaline-induced myocardial infarction (MI) models. The main polyphenolic compound identified in TOT was cichoric acid. The oxidative stress determinations showed the capacity of the dandelion tincture not only to decrease the total oxidative stress (TOS), the oxidative stress index (OSI), and the total antioxidant capacity (TAC), but also the malondialdehide (MDA), thiols (SH), and nitrites/nitrates (NOx) levels both in inflammation and MI models. In addition, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatin kinase-MB (CK-MB), and nuclear factor kappa B (NF-κB) parameters were decreased by the administration of the tincture. The results show that T. officinale could be considered a valuable source of natural compounds with important benefits in pathologies linked to oxidative stress. MDPI 2023-02-26 /pmc/articles/PMC10053582/ /pubmed/36986458 http://dx.doi.org/10.3390/ph16030358 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Epure, Alexandra
Pârvu, Alina E.
Vlase, Laurian
Benedec, Daniela
Hanganu, Daniela
Oniga, Ovidiu
Vlase, Ana-Maria
Ielciu, Irina
Toiu, Anca
Oniga, Ilioara
New Approaches on the Anti-Inflammatory and Cardioprotective Properties of Taraxacum officinale Tincture
title New Approaches on the Anti-Inflammatory and Cardioprotective Properties of Taraxacum officinale Tincture
title_full New Approaches on the Anti-Inflammatory and Cardioprotective Properties of Taraxacum officinale Tincture
title_fullStr New Approaches on the Anti-Inflammatory and Cardioprotective Properties of Taraxacum officinale Tincture
title_full_unstemmed New Approaches on the Anti-Inflammatory and Cardioprotective Properties of Taraxacum officinale Tincture
title_short New Approaches on the Anti-Inflammatory and Cardioprotective Properties of Taraxacum officinale Tincture
title_sort new approaches on the anti-inflammatory and cardioprotective properties of taraxacum officinale tincture
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053582/
https://www.ncbi.nlm.nih.gov/pubmed/36986458
http://dx.doi.org/10.3390/ph16030358
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