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Multilayer Methacrylate-Based Wound Dressing as a Therapeutic Tool for Targeted Pain Relief
This study presents an innovative wound dressing system that offers a highly effective therapeutic solution for treating painful wounds. By incorporating the widely used non-steroidal anti-inflammatory drug diclofenac, we have created an active wound dressing that can provide targeted pain relief wi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053588/ https://www.ncbi.nlm.nih.gov/pubmed/36984241 http://dx.doi.org/10.3390/ma16062361 |
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author | Zidarič, Tanja Skok, Kristijan Orthaber, Kristjan Pristovnik, Matevž Gradišnik, Lidija Maver, Tina Maver, Uroš |
author_facet | Zidarič, Tanja Skok, Kristijan Orthaber, Kristjan Pristovnik, Matevž Gradišnik, Lidija Maver, Tina Maver, Uroš |
author_sort | Zidarič, Tanja |
collection | PubMed |
description | This study presents an innovative wound dressing system that offers a highly effective therapeutic solution for treating painful wounds. By incorporating the widely used non-steroidal anti-inflammatory drug diclofenac, we have created an active wound dressing that can provide targeted pain relief with ease. The drug was embedded within a biocompatible matrix composed of polyhydroxyethyl methacrylate and polyhydroxypropyl methacrylate. The multilayer structure of the dressing, which allows for sustained drug release and an exact application, was achieved through the layer-by-layer coating technique and the inclusion of superparamagnetic iron platinum nanoparticles. The multilayered dressings’ physicochemical, structural, and morphological properties were characterised using various methods. The synergistic effect of the incorporated drug molecules and superparamagnetic nanoparticles on the surface roughness and release kinetics resulted in controlled drug release. In addition, the proposed multilayer wound dressings were found to be biocompatible with human skin fibroblasts. Our findings suggest that the developed wound dressing system can contribute to tailored therapeutic strategies for local pain relief. |
format | Online Article Text |
id | pubmed-10053588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100535882023-03-30 Multilayer Methacrylate-Based Wound Dressing as a Therapeutic Tool for Targeted Pain Relief Zidarič, Tanja Skok, Kristijan Orthaber, Kristjan Pristovnik, Matevž Gradišnik, Lidija Maver, Tina Maver, Uroš Materials (Basel) Article This study presents an innovative wound dressing system that offers a highly effective therapeutic solution for treating painful wounds. By incorporating the widely used non-steroidal anti-inflammatory drug diclofenac, we have created an active wound dressing that can provide targeted pain relief with ease. The drug was embedded within a biocompatible matrix composed of polyhydroxyethyl methacrylate and polyhydroxypropyl methacrylate. The multilayer structure of the dressing, which allows for sustained drug release and an exact application, was achieved through the layer-by-layer coating technique and the inclusion of superparamagnetic iron platinum nanoparticles. The multilayered dressings’ physicochemical, structural, and morphological properties were characterised using various methods. The synergistic effect of the incorporated drug molecules and superparamagnetic nanoparticles on the surface roughness and release kinetics resulted in controlled drug release. In addition, the proposed multilayer wound dressings were found to be biocompatible with human skin fibroblasts. Our findings suggest that the developed wound dressing system can contribute to tailored therapeutic strategies for local pain relief. MDPI 2023-03-15 /pmc/articles/PMC10053588/ /pubmed/36984241 http://dx.doi.org/10.3390/ma16062361 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zidarič, Tanja Skok, Kristijan Orthaber, Kristjan Pristovnik, Matevž Gradišnik, Lidija Maver, Tina Maver, Uroš Multilayer Methacrylate-Based Wound Dressing as a Therapeutic Tool for Targeted Pain Relief |
title | Multilayer Methacrylate-Based Wound Dressing as a Therapeutic Tool for Targeted Pain Relief |
title_full | Multilayer Methacrylate-Based Wound Dressing as a Therapeutic Tool for Targeted Pain Relief |
title_fullStr | Multilayer Methacrylate-Based Wound Dressing as a Therapeutic Tool for Targeted Pain Relief |
title_full_unstemmed | Multilayer Methacrylate-Based Wound Dressing as a Therapeutic Tool for Targeted Pain Relief |
title_short | Multilayer Methacrylate-Based Wound Dressing as a Therapeutic Tool for Targeted Pain Relief |
title_sort | multilayer methacrylate-based wound dressing as a therapeutic tool for targeted pain relief |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053588/ https://www.ncbi.nlm.nih.gov/pubmed/36984241 http://dx.doi.org/10.3390/ma16062361 |
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