Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation

BACKGROUND: Cardiovascular diseases, including diabetic cardiomyopathy, are major causes of death in people with type 2 diabetes. Aldose reductase activity is enhanced in hyperglycemic conditions, leading to altered cardiac energy metabolism and deterioration of cardiac function with adverse remodel...

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Detalles Bibliográficos
Autores principales: Gopal, Keshav, Karwi, Qutuba G., Tabatabaei Dakhili, Seyed Amirhossein, Wagg, Cory S., Zhang, Liyan, Sun, Qiuyu, Saed, Christina T., Panidarapu, Sai, Perfetti, Riccardo, Ramasamy, Ravichandran, Ussher, John R., Lopaschuk, Gary D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053619/
https://www.ncbi.nlm.nih.gov/pubmed/36978133
http://dx.doi.org/10.1186/s12933-023-01811-w

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