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Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible Association
Marked fatigue is common in patients with systemic lupus erythematosus (SLE). This study aimed to assess the association of sleep disorders, including obstructive sleep apnea (OSA), with SLE. Forty-two consecutive patients with SLE and 20 healthy controls were recruited and underwent a one-night amb...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053665/ https://www.ncbi.nlm.nih.gov/pubmed/36983852 http://dx.doi.org/10.3390/life13030697 |
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author | Meidan, Roni Elalouf, Ofir Tauman, Riva Furer, Victoria Polachek, Ari Wollman, Jonathan Eviatar, Tali Zisapel, Michael Levartovsky, David Seyman, Estelle Elkayam, Ori Paran, Daphna |
author_facet | Meidan, Roni Elalouf, Ofir Tauman, Riva Furer, Victoria Polachek, Ari Wollman, Jonathan Eviatar, Tali Zisapel, Michael Levartovsky, David Seyman, Estelle Elkayam, Ori Paran, Daphna |
author_sort | Meidan, Roni |
collection | PubMed |
description | Marked fatigue is common in patients with systemic lupus erythematosus (SLE). This study aimed to assess the association of sleep disorders, including obstructive sleep apnea (OSA), with SLE. Forty-two consecutive patients with SLE and 20 healthy controls were recruited and underwent a one-night ambulatory sleep examination. They completed questionnaires, including the Pittsburgh Sleep Quality Index (PSQI) and Functional Assessment of Chronic Illness Therapy (FACIT). SLE disease activity and damage were assessed by the SLE Disease Activity Index 2000 (SLEDAI-2K) and the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index (SDI). A significantly increased apnea/hypopnea index was noted in the SLE group compared to healthy controls (p = 0.004). SLE patients had higher rates of moderate-to-severe OSA (p = 0.04), PSQI (p = 0.001), and FACIT scores (p = 0.0008). Multivariate analysis revealed that the SDI was associated with OSA (p = 0.03). There was a positive association between SLEDAI-2K and moderate-to-severe OSA (p = 0.03). Patients with SLE had an increased prevalence of OSA and poorer quality of sleep compared to healthy controls. Our findings suggest that active disease and accumulated damage may be associated with OSA. These findings highlight the importance of identifying the presence of OSA in patients with SLE. |
format | Online Article Text |
id | pubmed-10053665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100536652023-03-30 Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible Association Meidan, Roni Elalouf, Ofir Tauman, Riva Furer, Victoria Polachek, Ari Wollman, Jonathan Eviatar, Tali Zisapel, Michael Levartovsky, David Seyman, Estelle Elkayam, Ori Paran, Daphna Life (Basel) Article Marked fatigue is common in patients with systemic lupus erythematosus (SLE). This study aimed to assess the association of sleep disorders, including obstructive sleep apnea (OSA), with SLE. Forty-two consecutive patients with SLE and 20 healthy controls were recruited and underwent a one-night ambulatory sleep examination. They completed questionnaires, including the Pittsburgh Sleep Quality Index (PSQI) and Functional Assessment of Chronic Illness Therapy (FACIT). SLE disease activity and damage were assessed by the SLE Disease Activity Index 2000 (SLEDAI-2K) and the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index (SDI). A significantly increased apnea/hypopnea index was noted in the SLE group compared to healthy controls (p = 0.004). SLE patients had higher rates of moderate-to-severe OSA (p = 0.04), PSQI (p = 0.001), and FACIT scores (p = 0.0008). Multivariate analysis revealed that the SDI was associated with OSA (p = 0.03). There was a positive association between SLEDAI-2K and moderate-to-severe OSA (p = 0.03). Patients with SLE had an increased prevalence of OSA and poorer quality of sleep compared to healthy controls. Our findings suggest that active disease and accumulated damage may be associated with OSA. These findings highlight the importance of identifying the presence of OSA in patients with SLE. MDPI 2023-03-05 /pmc/articles/PMC10053665/ /pubmed/36983852 http://dx.doi.org/10.3390/life13030697 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Meidan, Roni Elalouf, Ofir Tauman, Riva Furer, Victoria Polachek, Ari Wollman, Jonathan Eviatar, Tali Zisapel, Michael Levartovsky, David Seyman, Estelle Elkayam, Ori Paran, Daphna Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible Association |
title | Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible Association |
title_full | Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible Association |
title_fullStr | Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible Association |
title_full_unstemmed | Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible Association |
title_short | Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible Association |
title_sort | systemic lupus erythematous and obstructive sleep apnea: a possible association |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053665/ https://www.ncbi.nlm.nih.gov/pubmed/36983852 http://dx.doi.org/10.3390/life13030697 |
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