Structural basis of the inhibition of cystathionine γ‐lyase from Toxoplasma gondii by propargylglycine and cysteine

Cystathionine γ‐lyase (CGL) is a PLP‐dependent enzyme that catalyzes the last step of the reverse transsulfuration route for endogenous cysteine biosynthesis. The canonical CGL‐catalyzed process consists of an α,γ‐elimination reaction that breaks down cystathionine into cysteine, α‐ketobutyrate, and...

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Detalles Bibliográficos
Autores principales: Fernández‐Rodríguez, Carmen, Conter, Carolina, Oyenarte, Iker, Favretto, Filippo, Quintana, Iban, Martinez‐Chantar, Maria Luz, Astegno, Alessandra, Martínez‐Cruz, Luis Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Full‐length Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053738/
https://www.ncbi.nlm.nih.gov/pubmed/36883335
http://dx.doi.org/10.1002/pro.4619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053738/
https://www.ncbi.nlm.nih.gov/pubmed/36883335
http://dx.doi.org/10.1002/pro.4619

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