Synthesis and Structure–Activity Analysis of Novel Potential Antifungal Cyclotryptamine Alkaloid Derivatives

A total of 39 novel cyclotryptamine alkaloid derivatives were prepared from 2-(1H-indol-3-yl) acetonitrile. The prepared compounds were evaluated against six plant pathogen fungi. Bioassay results revealed that most of the compounds displayed higher in vitro antifungal activities than the positive c...

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Detalles Bibliográficos
Autores principales: Yang, Yazhou, Zhou, Yujie, Jiang, Qiaoju, Tan, Yi, Wu, Wenbin, Han, Ke, Zhu, Rui, Zheng, Shaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053776/
https://www.ncbi.nlm.nih.gov/pubmed/36985588
http://dx.doi.org/10.3390/molecules28062617
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author Yang, Yazhou
Zhou, Yujie
Jiang, Qiaoju
Tan, Yi
Wu, Wenbin
Han, Ke
Zhu, Rui
Zheng, Shaojun
author_facet Yang, Yazhou
Zhou, Yujie
Jiang, Qiaoju
Tan, Yi
Wu, Wenbin
Han, Ke
Zhu, Rui
Zheng, Shaojun
author_sort Yang, Yazhou
collection PubMed
description A total of 39 novel cyclotryptamine alkaloid derivatives were prepared from 2-(1H-indol-3-yl) acetonitrile. The prepared compounds were evaluated against six plant pathogen fungi. Bioassay results revealed that most of the compounds displayed higher in vitro antifungal activities than the positive control. Notably, compound b2 displayed the broadest and most effective activity among the tested cyclotryptamine alkaloid derivatives and might be a novel potential leading compound for further development as an antifungal agent.
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spelling pubmed-100537762023-03-30 Synthesis and Structure–Activity Analysis of Novel Potential Antifungal Cyclotryptamine Alkaloid Derivatives Yang, Yazhou Zhou, Yujie Jiang, Qiaoju Tan, Yi Wu, Wenbin Han, Ke Zhu, Rui Zheng, Shaojun Molecules Article A total of 39 novel cyclotryptamine alkaloid derivatives were prepared from 2-(1H-indol-3-yl) acetonitrile. The prepared compounds were evaluated against six plant pathogen fungi. Bioassay results revealed that most of the compounds displayed higher in vitro antifungal activities than the positive control. Notably, compound b2 displayed the broadest and most effective activity among the tested cyclotryptamine alkaloid derivatives and might be a novel potential leading compound for further development as an antifungal agent. MDPI 2023-03-13 /pmc/articles/PMC10053776/ /pubmed/36985588 http://dx.doi.org/10.3390/molecules28062617 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Yazhou
Zhou, Yujie
Jiang, Qiaoju
Tan, Yi
Wu, Wenbin
Han, Ke
Zhu, Rui
Zheng, Shaojun
Synthesis and Structure–Activity Analysis of Novel Potential Antifungal Cyclotryptamine Alkaloid Derivatives
title Synthesis and Structure–Activity Analysis of Novel Potential Antifungal Cyclotryptamine Alkaloid Derivatives
title_full Synthesis and Structure–Activity Analysis of Novel Potential Antifungal Cyclotryptamine Alkaloid Derivatives
title_fullStr Synthesis and Structure–Activity Analysis of Novel Potential Antifungal Cyclotryptamine Alkaloid Derivatives
title_full_unstemmed Synthesis and Structure–Activity Analysis of Novel Potential Antifungal Cyclotryptamine Alkaloid Derivatives
title_short Synthesis and Structure–Activity Analysis of Novel Potential Antifungal Cyclotryptamine Alkaloid Derivatives
title_sort synthesis and structure–activity analysis of novel potential antifungal cyclotryptamine alkaloid derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053776/
https://www.ncbi.nlm.nih.gov/pubmed/36985588
http://dx.doi.org/10.3390/molecules28062617
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