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A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression
Probiotics are currently the subject of intensive research pursuits and also represent a multi-billion-dollar global industry given their vast potential to improve human health. In addition, mental health represents a key domain of healthcare, which currently has limited, adverse-effect prone treatm...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053794/ https://www.ncbi.nlm.nih.gov/pubmed/36986112 http://dx.doi.org/10.3390/nu15061382 |
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author | Johnson, Dinyadarshini Letchumanan, Vengadesh Thum, Chern Choong Thurairajasingam, Sivakumar Lee, Learn-Han |
author_facet | Johnson, Dinyadarshini Letchumanan, Vengadesh Thum, Chern Choong Thurairajasingam, Sivakumar Lee, Learn-Han |
author_sort | Johnson, Dinyadarshini |
collection | PubMed |
description | Probiotics are currently the subject of intensive research pursuits and also represent a multi-billion-dollar global industry given their vast potential to improve human health. In addition, mental health represents a key domain of healthcare, which currently has limited, adverse-effect prone treatment options, and probiotics may hold the potential to be a novel, customizable treatment for depression. Clinical depression is a common, potentially debilitating condition that may be amenable to a precision psychiatry-based approach utilizing probiotics. Although our understanding has not yet reached a sufficient level, this could be a therapeutic approach that can be tailored for specific individuals with their own unique set of characteristics and health issues. Scientifically, the use of probiotics as a treatment for depression has a valid basis rooted in the microbiota-gut-brain axis (MGBA) mechanisms, which play a role in the pathophysiology of depression. In theory, probiotics appear to be ideal as adjunct therapeutics for major depressive disorder (MDD) and as stand-alone therapeutics for mild MDD and may potentially revolutionize the treatment of depressive disorders. Although there is a wide range of probiotics and an almost limitless range of therapeutic combinations, this review aims to narrow the focus to the most widely commercialized and studied strains, namely Lactobacillus and Bifidobacterium, and to bring together the arguments for their usage in patients with major depressive disorder (MDD). Clinicians, scientists, and industrialists are critical stakeholders in exploring this groundbreaking concept. |
format | Online Article Text |
id | pubmed-10053794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100537942023-03-30 A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression Johnson, Dinyadarshini Letchumanan, Vengadesh Thum, Chern Choong Thurairajasingam, Sivakumar Lee, Learn-Han Nutrients Review Probiotics are currently the subject of intensive research pursuits and also represent a multi-billion-dollar global industry given their vast potential to improve human health. In addition, mental health represents a key domain of healthcare, which currently has limited, adverse-effect prone treatment options, and probiotics may hold the potential to be a novel, customizable treatment for depression. Clinical depression is a common, potentially debilitating condition that may be amenable to a precision psychiatry-based approach utilizing probiotics. Although our understanding has not yet reached a sufficient level, this could be a therapeutic approach that can be tailored for specific individuals with their own unique set of characteristics and health issues. Scientifically, the use of probiotics as a treatment for depression has a valid basis rooted in the microbiota-gut-brain axis (MGBA) mechanisms, which play a role in the pathophysiology of depression. In theory, probiotics appear to be ideal as adjunct therapeutics for major depressive disorder (MDD) and as stand-alone therapeutics for mild MDD and may potentially revolutionize the treatment of depressive disorders. Although there is a wide range of probiotics and an almost limitless range of therapeutic combinations, this review aims to narrow the focus to the most widely commercialized and studied strains, namely Lactobacillus and Bifidobacterium, and to bring together the arguments for their usage in patients with major depressive disorder (MDD). Clinicians, scientists, and industrialists are critical stakeholders in exploring this groundbreaking concept. MDPI 2023-03-13 /pmc/articles/PMC10053794/ /pubmed/36986112 http://dx.doi.org/10.3390/nu15061382 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Johnson, Dinyadarshini Letchumanan, Vengadesh Thum, Chern Choong Thurairajasingam, Sivakumar Lee, Learn-Han A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression |
title | A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression |
title_full | A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression |
title_fullStr | A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression |
title_full_unstemmed | A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression |
title_short | A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression |
title_sort | microbial-based approach to mental health: the potential of probiotics in the treatment of depression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053794/ https://www.ncbi.nlm.nih.gov/pubmed/36986112 http://dx.doi.org/10.3390/nu15061382 |
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