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Building a Human Physiologically Based Pharmacokinetic Model for Aflatoxin B1 to Simulate Interactions with Drugs

Mycotoxins such as aflatoxin B1 (AFB1) are secondary fungal metabolites present in food commodities and part of one’s daily exposure, especially in certain regions, e.g., sub-Saharan Africa. AFB1 is mostly metabolised by cytochrome P450 (CYP) enzymes, namely, CYP1A2 and CYP3A4. As a consequence of c...

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Detalles Bibliográficos
Autores principales:	Lootens, Orphélie, De Boevre, Marthe, Ning, Jia, Gasthuys, Elke, Van Bocxlaer, Jan, De Saeger, Sarah, Vermeulen, An
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053806/ https://www.ncbi.nlm.nih.gov/pubmed/36986755 http://dx.doi.org/10.3390/pharmaceutics15030894

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