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The ClC-2 Chloride Channel Activator, Lubiprostone, Improves Intestinal Barrier Function in Biopsies from Crohn’s Disease but Not Ulcerative Colitis Patients

The prostone analog, lubiprostone, is approved to manage constipation-predominant irritable bowel syndrome. Lubiprostone also protects intestinal mucosal barrier function in animal models of colitis. The aim of this study was to determine if lubiprostone improves barrier properties in isolated colon...

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Detalles Bibliográficos
Autores principales:	Park, Young Su, Kang, Sang Bum, Marchelletta, Ronald R., Penrose, Harrison M., Ruiter-Visser, Roos, Jung, Barbara, Docherty, Michael J., Boland, Brigid S., Sandborn, William J., McCole, Declan F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053841/ https://www.ncbi.nlm.nih.gov/pubmed/36986672 http://dx.doi.org/10.3390/pharmaceutics15030811

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