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Regulation of Pre-mRNA Splicing: Indispensable Role of Post-Translational Modifications of Splicing Factors
Pre-mRNA splicing is a process used by eukaryotic cells to generate messenger RNAs that can be translated into proteins. During splicing, the non-coding regions of the RNAs (introns) are removed from pre-mRNAs and the coding regions (exons) are joined together, resulting in mature mRNAs. The particu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053845/ https://www.ncbi.nlm.nih.gov/pubmed/36983760 http://dx.doi.org/10.3390/life13030604 |
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author | Kretova, Miroslava Selicky, Tomas Cipakova, Ingrid Cipak, Lubos |
author_facet | Kretova, Miroslava Selicky, Tomas Cipakova, Ingrid Cipak, Lubos |
author_sort | Kretova, Miroslava |
collection | PubMed |
description | Pre-mRNA splicing is a process used by eukaryotic cells to generate messenger RNAs that can be translated into proteins. During splicing, the non-coding regions of the RNAs (introns) are removed from pre-mRNAs and the coding regions (exons) are joined together, resulting in mature mRNAs. The particular steps of splicing are executed by the multimegadalton complex called a spliceosome. This complex is composed of small nuclear ribonucleoproteins, various splicing factors, and other regulatory and auxiliary proteins. In recent years, various post-translational modifications of splicing factors have been shown to contribute significantly to regulation of processes involved in pre-mRNA splicing. In this review, we provide an overview of the most important post-translational modifications of splicing factors that are indispensable for their normal function during pre-mRNA splicing (i.e., phosphorylation, acetylation, methylation, ubiquitination and sumoylation). Moreover, we also discuss how the defects in regulation of splicing factors are related to the development of cancer. |
format | Online Article Text |
id | pubmed-10053845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100538452023-03-30 Regulation of Pre-mRNA Splicing: Indispensable Role of Post-Translational Modifications of Splicing Factors Kretova, Miroslava Selicky, Tomas Cipakova, Ingrid Cipak, Lubos Life (Basel) Review Pre-mRNA splicing is a process used by eukaryotic cells to generate messenger RNAs that can be translated into proteins. During splicing, the non-coding regions of the RNAs (introns) are removed from pre-mRNAs and the coding regions (exons) are joined together, resulting in mature mRNAs. The particular steps of splicing are executed by the multimegadalton complex called a spliceosome. This complex is composed of small nuclear ribonucleoproteins, various splicing factors, and other regulatory and auxiliary proteins. In recent years, various post-translational modifications of splicing factors have been shown to contribute significantly to regulation of processes involved in pre-mRNA splicing. In this review, we provide an overview of the most important post-translational modifications of splicing factors that are indispensable for their normal function during pre-mRNA splicing (i.e., phosphorylation, acetylation, methylation, ubiquitination and sumoylation). Moreover, we also discuss how the defects in regulation of splicing factors are related to the development of cancer. MDPI 2023-02-21 /pmc/articles/PMC10053845/ /pubmed/36983760 http://dx.doi.org/10.3390/life13030604 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kretova, Miroslava Selicky, Tomas Cipakova, Ingrid Cipak, Lubos Regulation of Pre-mRNA Splicing: Indispensable Role of Post-Translational Modifications of Splicing Factors |
title | Regulation of Pre-mRNA Splicing: Indispensable Role of Post-Translational Modifications of Splicing Factors |
title_full | Regulation of Pre-mRNA Splicing: Indispensable Role of Post-Translational Modifications of Splicing Factors |
title_fullStr | Regulation of Pre-mRNA Splicing: Indispensable Role of Post-Translational Modifications of Splicing Factors |
title_full_unstemmed | Regulation of Pre-mRNA Splicing: Indispensable Role of Post-Translational Modifications of Splicing Factors |
title_short | Regulation of Pre-mRNA Splicing: Indispensable Role of Post-Translational Modifications of Splicing Factors |
title_sort | regulation of pre-mrna splicing: indispensable role of post-translational modifications of splicing factors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053845/ https://www.ncbi.nlm.nih.gov/pubmed/36983760 http://dx.doi.org/10.3390/life13030604 |
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