Cargando…
Relationships between Circulating Sclerostin, Bone Marrow Adiposity, Other Adipose Deposits and Lean Mass in Post-Menopausal Women
Sclerostin is a Wnt signaling pathway inhibitor that negatively regulates bone formation. Bone-marrow-derived stromal cell (BMSC) differentiation is influenced by the Wnt pathway, leading to the hypothesis that higher levels of sclerostin might be associated with an increase in bone marrow adiposity...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053867/ https://www.ncbi.nlm.nih.gov/pubmed/36982995 http://dx.doi.org/10.3390/ijms24065922 |
_version_ | 1785015515118305280 |
---|---|
author | Courtalin, Marion Bertheaume, Nicolas Badr, Sammy During, Alexandrine Lombardo, Daniela Deken, Valérie Cortet, Bernard Clabaut, Aline Paccou, Julien |
author_facet | Courtalin, Marion Bertheaume, Nicolas Badr, Sammy During, Alexandrine Lombardo, Daniela Deken, Valérie Cortet, Bernard Clabaut, Aline Paccou, Julien |
author_sort | Courtalin, Marion |
collection | PubMed |
description | Sclerostin is a Wnt signaling pathway inhibitor that negatively regulates bone formation. Bone-marrow-derived stromal cell (BMSC) differentiation is influenced by the Wnt pathway, leading to the hypothesis that higher levels of sclerostin might be associated with an increase in bone marrow adiposity (BMA). The main purpose of this study was to determine whether a relationship exists between circulating sclerostin and BMA in post-menopausal women with and without fragility fractures. The relationships between circulating sclerostin and body composition parameters were then examined. The outcomes measures included vertebral and hip proton density fat fraction (PDFF) using the water fat imaging (WFI) MRI method; DXA scans; and laboratory measurements, including serum sclerostin. In 199 participants, no significant correlations were found between serum sclerostin and PDFF. In both groups, serum sclerostin was correlated positively with bone mineral density (R = 0.27 to 0.56) and negatively with renal function (R = −0.22 to −0.29). Serum sclerostin correlated negatively with visceral adiposity in both groups (R = −0.24 to −0.32). Serum sclerostin correlated negatively with total body fat (R = −0.47) and appendicular lean mass (R = −0.26) in the fracture group, but not in the controls. No evidence of a relationship between serum sclerostin and BMA was found. However, serum sclerostin was negatively correlated with body composition components, such as visceral adiposity, total body fat and appendicular lean mass. |
format | Online Article Text |
id | pubmed-10053867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100538672023-03-30 Relationships between Circulating Sclerostin, Bone Marrow Adiposity, Other Adipose Deposits and Lean Mass in Post-Menopausal Women Courtalin, Marion Bertheaume, Nicolas Badr, Sammy During, Alexandrine Lombardo, Daniela Deken, Valérie Cortet, Bernard Clabaut, Aline Paccou, Julien Int J Mol Sci Article Sclerostin is a Wnt signaling pathway inhibitor that negatively regulates bone formation. Bone-marrow-derived stromal cell (BMSC) differentiation is influenced by the Wnt pathway, leading to the hypothesis that higher levels of sclerostin might be associated with an increase in bone marrow adiposity (BMA). The main purpose of this study was to determine whether a relationship exists between circulating sclerostin and BMA in post-menopausal women with and without fragility fractures. The relationships between circulating sclerostin and body composition parameters were then examined. The outcomes measures included vertebral and hip proton density fat fraction (PDFF) using the water fat imaging (WFI) MRI method; DXA scans; and laboratory measurements, including serum sclerostin. In 199 participants, no significant correlations were found between serum sclerostin and PDFF. In both groups, serum sclerostin was correlated positively with bone mineral density (R = 0.27 to 0.56) and negatively with renal function (R = −0.22 to −0.29). Serum sclerostin correlated negatively with visceral adiposity in both groups (R = −0.24 to −0.32). Serum sclerostin correlated negatively with total body fat (R = −0.47) and appendicular lean mass (R = −0.26) in the fracture group, but not in the controls. No evidence of a relationship between serum sclerostin and BMA was found. However, serum sclerostin was negatively correlated with body composition components, such as visceral adiposity, total body fat and appendicular lean mass. MDPI 2023-03-21 /pmc/articles/PMC10053867/ /pubmed/36982995 http://dx.doi.org/10.3390/ijms24065922 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Courtalin, Marion Bertheaume, Nicolas Badr, Sammy During, Alexandrine Lombardo, Daniela Deken, Valérie Cortet, Bernard Clabaut, Aline Paccou, Julien Relationships between Circulating Sclerostin, Bone Marrow Adiposity, Other Adipose Deposits and Lean Mass in Post-Menopausal Women |
title | Relationships between Circulating Sclerostin, Bone Marrow Adiposity, Other Adipose Deposits and Lean Mass in Post-Menopausal Women |
title_full | Relationships between Circulating Sclerostin, Bone Marrow Adiposity, Other Adipose Deposits and Lean Mass in Post-Menopausal Women |
title_fullStr | Relationships between Circulating Sclerostin, Bone Marrow Adiposity, Other Adipose Deposits and Lean Mass in Post-Menopausal Women |
title_full_unstemmed | Relationships between Circulating Sclerostin, Bone Marrow Adiposity, Other Adipose Deposits and Lean Mass in Post-Menopausal Women |
title_short | Relationships between Circulating Sclerostin, Bone Marrow Adiposity, Other Adipose Deposits and Lean Mass in Post-Menopausal Women |
title_sort | relationships between circulating sclerostin, bone marrow adiposity, other adipose deposits and lean mass in post-menopausal women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053867/ https://www.ncbi.nlm.nih.gov/pubmed/36982995 http://dx.doi.org/10.3390/ijms24065922 |
work_keys_str_mv | AT courtalinmarion relationshipsbetweencirculatingsclerostinbonemarrowadiposityotheradiposedepositsandleanmassinpostmenopausalwomen AT bertheaumenicolas relationshipsbetweencirculatingsclerostinbonemarrowadiposityotheradiposedepositsandleanmassinpostmenopausalwomen AT badrsammy relationshipsbetweencirculatingsclerostinbonemarrowadiposityotheradiposedepositsandleanmassinpostmenopausalwomen AT duringalexandrine relationshipsbetweencirculatingsclerostinbonemarrowadiposityotheradiposedepositsandleanmassinpostmenopausalwomen AT lombardodaniela relationshipsbetweencirculatingsclerostinbonemarrowadiposityotheradiposedepositsandleanmassinpostmenopausalwomen AT dekenvalerie relationshipsbetweencirculatingsclerostinbonemarrowadiposityotheradiposedepositsandleanmassinpostmenopausalwomen AT cortetbernard relationshipsbetweencirculatingsclerostinbonemarrowadiposityotheradiposedepositsandleanmassinpostmenopausalwomen AT clabautaline relationshipsbetweencirculatingsclerostinbonemarrowadiposityotheradiposedepositsandleanmassinpostmenopausalwomen AT paccoujulien relationshipsbetweencirculatingsclerostinbonemarrowadiposityotheradiposedepositsandleanmassinpostmenopausalwomen |