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Unilateral Pleural Effusion after Third Dose of BNT162b2 mRNA Vaccination: Case Report

Vaccination remains the best strategy against coronavirus disease 2019 (COVID-19) in terms of prevention. The efficacy and safety of COVID-19 vaccines is supported by well-designed clinical trials that recruited many participants. It is well-known that vaccination is associated with local side effec...

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Autores principales: Athanasiou, Nikolaos K., Antonoglou, Archontoula, Ioannou, Marios, Jahaj, Edison, Katsaounou, Paraskevi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054106/
https://www.ncbi.nlm.nih.gov/pubmed/36983574
http://dx.doi.org/10.3390/jpm13030391
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author Athanasiou, Nikolaos K.
Antonoglou, Archontoula
Ioannou, Marios
Jahaj, Edison
Katsaounou, Paraskevi
author_facet Athanasiou, Nikolaos K.
Antonoglou, Archontoula
Ioannou, Marios
Jahaj, Edison
Katsaounou, Paraskevi
author_sort Athanasiou, Nikolaos K.
collection PubMed
description Vaccination remains the best strategy against coronavirus disease 2019 (COVID-19) in terms of prevention. The efficacy and safety of COVID-19 vaccines is supported by well-designed clinical trials that recruited many participants. It is well-known that vaccination is associated with local side effects related to the injection site, and mild, systemic side effects. However, there has been an increase in the occurrence of what is known as infrequent adverse effects in the population of vaccinated individuals in real life. We present the case of a 46-year-old woman with no past medical history, who presented with a sharp chest pain with deep inspiration, a few days after receiving the third dose of the Pfizer-BioNTech COVID-19 mRNA vaccine (BNT162b2). There is an association between the BNT16b2 vaccination and myocarditis, pericarditis, and even bilateral pleural effusions. To the best of our knowledge, this is the first report featuring a unilateral pleural effusion in a patient with no known past medical history, who did not develop cardiac involvement nor have any viral infection. The aim of our report is to inform health professionals of the possibility of encountering this rare adverse event in their daily practice, as the population of individuals who are receiving additional vaccine doses is increasing steadily.
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spelling pubmed-100541062023-03-30 Unilateral Pleural Effusion after Third Dose of BNT162b2 mRNA Vaccination: Case Report Athanasiou, Nikolaos K. Antonoglou, Archontoula Ioannou, Marios Jahaj, Edison Katsaounou, Paraskevi J Pers Med Case Report Vaccination remains the best strategy against coronavirus disease 2019 (COVID-19) in terms of prevention. The efficacy and safety of COVID-19 vaccines is supported by well-designed clinical trials that recruited many participants. It is well-known that vaccination is associated with local side effects related to the injection site, and mild, systemic side effects. However, there has been an increase in the occurrence of what is known as infrequent adverse effects in the population of vaccinated individuals in real life. We present the case of a 46-year-old woman with no past medical history, who presented with a sharp chest pain with deep inspiration, a few days after receiving the third dose of the Pfizer-BioNTech COVID-19 mRNA vaccine (BNT162b2). There is an association between the BNT16b2 vaccination and myocarditis, pericarditis, and even bilateral pleural effusions. To the best of our knowledge, this is the first report featuring a unilateral pleural effusion in a patient with no known past medical history, who did not develop cardiac involvement nor have any viral infection. The aim of our report is to inform health professionals of the possibility of encountering this rare adverse event in their daily practice, as the population of individuals who are receiving additional vaccine doses is increasing steadily. MDPI 2023-02-23 /pmc/articles/PMC10054106/ /pubmed/36983574 http://dx.doi.org/10.3390/jpm13030391 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Athanasiou, Nikolaos K.
Antonoglou, Archontoula
Ioannou, Marios
Jahaj, Edison
Katsaounou, Paraskevi
Unilateral Pleural Effusion after Third Dose of BNT162b2 mRNA Vaccination: Case Report
title Unilateral Pleural Effusion after Third Dose of BNT162b2 mRNA Vaccination: Case Report
title_full Unilateral Pleural Effusion after Third Dose of BNT162b2 mRNA Vaccination: Case Report
title_fullStr Unilateral Pleural Effusion after Third Dose of BNT162b2 mRNA Vaccination: Case Report
title_full_unstemmed Unilateral Pleural Effusion after Third Dose of BNT162b2 mRNA Vaccination: Case Report
title_short Unilateral Pleural Effusion after Third Dose of BNT162b2 mRNA Vaccination: Case Report
title_sort unilateral pleural effusion after third dose of bnt162b2 mrna vaccination: case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054106/
https://www.ncbi.nlm.nih.gov/pubmed/36983574
http://dx.doi.org/10.3390/jpm13030391
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