Pruritogenic Mediators and New Antipruritic Drugs in Atopic Dermatitis

Atopic dermatitis (AD) is a common highly pruritic chronic inflammatory skin disorder affecting 5–20% of children worldwide, while the prevalence in adults varies from 7 to 10%. Patients with AD experience intense pruritus that could lead to sleep disturbance and impaired quality of life. Here, we a...

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Detalles Bibliográficos
Autores principales: Koumaki, Dimitra, Gregoriou, Stamatios, Evangelou, George, Krasagakis, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054239/
https://www.ncbi.nlm.nih.gov/pubmed/36983094
http://dx.doi.org/10.3390/jcm12062091
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author Koumaki, Dimitra
Gregoriou, Stamatios
Evangelou, George
Krasagakis, Konstantinos
author_facet Koumaki, Dimitra
Gregoriou, Stamatios
Evangelou, George
Krasagakis, Konstantinos
author_sort Koumaki, Dimitra
collection PubMed
description Atopic dermatitis (AD) is a common highly pruritic chronic inflammatory skin disorder affecting 5–20% of children worldwide, while the prevalence in adults varies from 7 to 10%. Patients with AD experience intense pruritus that could lead to sleep disturbance and impaired quality of life. Here, we analyze the pathophysiology of itchiness in AD. We extensively review the histamine-dependent and histamine-independent pruritogens. Several receptors, substance P, secreted molecules, chemokines, and cytokines are involved as mediators in chronic itch. We also, summarize the new emerging antipruritic drugs in atopic dermatitis.
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spelling pubmed-100542392023-03-30 Pruritogenic Mediators and New Antipruritic Drugs in Atopic Dermatitis Koumaki, Dimitra Gregoriou, Stamatios Evangelou, George Krasagakis, Konstantinos J Clin Med Review Atopic dermatitis (AD) is a common highly pruritic chronic inflammatory skin disorder affecting 5–20% of children worldwide, while the prevalence in adults varies from 7 to 10%. Patients with AD experience intense pruritus that could lead to sleep disturbance and impaired quality of life. Here, we analyze the pathophysiology of itchiness in AD. We extensively review the histamine-dependent and histamine-independent pruritogens. Several receptors, substance P, secreted molecules, chemokines, and cytokines are involved as mediators in chronic itch. We also, summarize the new emerging antipruritic drugs in atopic dermatitis. MDPI 2023-03-07 /pmc/articles/PMC10054239/ /pubmed/36983094 http://dx.doi.org/10.3390/jcm12062091 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Koumaki, Dimitra
Gregoriou, Stamatios
Evangelou, George
Krasagakis, Konstantinos
Pruritogenic Mediators and New Antipruritic Drugs in Atopic Dermatitis
title Pruritogenic Mediators and New Antipruritic Drugs in Atopic Dermatitis
title_full Pruritogenic Mediators and New Antipruritic Drugs in Atopic Dermatitis
title_fullStr Pruritogenic Mediators and New Antipruritic Drugs in Atopic Dermatitis
title_full_unstemmed Pruritogenic Mediators and New Antipruritic Drugs in Atopic Dermatitis
title_short Pruritogenic Mediators and New Antipruritic Drugs in Atopic Dermatitis
title_sort pruritogenic mediators and new antipruritic drugs in atopic dermatitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054239/
https://www.ncbi.nlm.nih.gov/pubmed/36983094
http://dx.doi.org/10.3390/jcm12062091
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