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‘Candidatus Rickettsia andeanae’ and Probable Exclusion of Rickettsia parkeri in Ticks from Dogs in a Natural Area of the Pampa Biome in Brazil

Spotted fever illness caused by the tick-borne pathogen Rickettsia parkeri has emerged in the Pampa biome in southern Brazil, where the tick Amblyomma tigrinum is implicated as the main vector. Because domestic dogs are commonly parasitized by A. tigrinum, this canid is also a suitable sentinel for...

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Autores principales: Krawczak, Felipe S., Binder, Lina C., Gregori, Fábio, Martins, Thiago F., Pádua, Gracielle T., Sponchiado, Jonas, Melo, Geruza L., Polo, Gina, Labruna, Marcelo B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054268/
https://www.ncbi.nlm.nih.gov/pubmed/36986368
http://dx.doi.org/10.3390/pathogens12030446
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author Krawczak, Felipe S.
Binder, Lina C.
Gregori, Fábio
Martins, Thiago F.
Pádua, Gracielle T.
Sponchiado, Jonas
Melo, Geruza L.
Polo, Gina
Labruna, Marcelo B.
author_facet Krawczak, Felipe S.
Binder, Lina C.
Gregori, Fábio
Martins, Thiago F.
Pádua, Gracielle T.
Sponchiado, Jonas
Melo, Geruza L.
Polo, Gina
Labruna, Marcelo B.
author_sort Krawczak, Felipe S.
collection PubMed
description Spotted fever illness caused by the tick-borne pathogen Rickettsia parkeri has emerged in the Pampa biome in southern Brazil, where the tick Amblyomma tigrinum is implicated as the main vector. Because domestic dogs are commonly parasitized by A. tigrinum, this canid is also a suitable sentinel for R. parkeri-associated spotted fever. Herein, we investigate rickettsial infection in ticks, domestic dogs and small mammals in a natural reserve of the Pampa biome in southern Brazil. The ticks A. tigrinum, Amblyomma aureolatum and Rhipicephalus sanguineus were collected from dogs. Molecular analyses of ticks did not detect R. parkeri; however, at least 34% (21/61) of the A. tigrinum ticks were infected by the non-pathogenic agent ‘Candidatus Rickettsia andeanae’. Serological analyses revealed that only 14% and 3% of 36 dogs and 34 small mammals, respectively, were exposed to rickettsial antigens. These results indicate that the study area is not endemic for R. parkeri rickettsiosis. We tabulated 10 studies that reported rickettsial infection in A. tigrinum populations from South America. There was a strong negative correlation between the infection rates by R. parkeri and ‘Candidatus R. andeanae’ in A. tigrinum populations. We propose that high infection rates by ‘Candidatus R. andeanae’ might promote the exclusion of R. parkeri from A. tigrinum populations. The mechanisms for such exclusion are yet to be elucidated.
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spelling pubmed-100542682023-03-30 ‘Candidatus Rickettsia andeanae’ and Probable Exclusion of Rickettsia parkeri in Ticks from Dogs in a Natural Area of the Pampa Biome in Brazil Krawczak, Felipe S. Binder, Lina C. Gregori, Fábio Martins, Thiago F. Pádua, Gracielle T. Sponchiado, Jonas Melo, Geruza L. Polo, Gina Labruna, Marcelo B. Pathogens Article Spotted fever illness caused by the tick-borne pathogen Rickettsia parkeri has emerged in the Pampa biome in southern Brazil, where the tick Amblyomma tigrinum is implicated as the main vector. Because domestic dogs are commonly parasitized by A. tigrinum, this canid is also a suitable sentinel for R. parkeri-associated spotted fever. Herein, we investigate rickettsial infection in ticks, domestic dogs and small mammals in a natural reserve of the Pampa biome in southern Brazil. The ticks A. tigrinum, Amblyomma aureolatum and Rhipicephalus sanguineus were collected from dogs. Molecular analyses of ticks did not detect R. parkeri; however, at least 34% (21/61) of the A. tigrinum ticks were infected by the non-pathogenic agent ‘Candidatus Rickettsia andeanae’. Serological analyses revealed that only 14% and 3% of 36 dogs and 34 small mammals, respectively, were exposed to rickettsial antigens. These results indicate that the study area is not endemic for R. parkeri rickettsiosis. We tabulated 10 studies that reported rickettsial infection in A. tigrinum populations from South America. There was a strong negative correlation between the infection rates by R. parkeri and ‘Candidatus R. andeanae’ in A. tigrinum populations. We propose that high infection rates by ‘Candidatus R. andeanae’ might promote the exclusion of R. parkeri from A. tigrinum populations. The mechanisms for such exclusion are yet to be elucidated. MDPI 2023-03-12 /pmc/articles/PMC10054268/ /pubmed/36986368 http://dx.doi.org/10.3390/pathogens12030446 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Krawczak, Felipe S.
Binder, Lina C.
Gregori, Fábio
Martins, Thiago F.
Pádua, Gracielle T.
Sponchiado, Jonas
Melo, Geruza L.
Polo, Gina
Labruna, Marcelo B.
‘Candidatus Rickettsia andeanae’ and Probable Exclusion of Rickettsia parkeri in Ticks from Dogs in a Natural Area of the Pampa Biome in Brazil
title ‘Candidatus Rickettsia andeanae’ and Probable Exclusion of Rickettsia parkeri in Ticks from Dogs in a Natural Area of the Pampa Biome in Brazil
title_full ‘Candidatus Rickettsia andeanae’ and Probable Exclusion of Rickettsia parkeri in Ticks from Dogs in a Natural Area of the Pampa Biome in Brazil
title_fullStr ‘Candidatus Rickettsia andeanae’ and Probable Exclusion of Rickettsia parkeri in Ticks from Dogs in a Natural Area of the Pampa Biome in Brazil
title_full_unstemmed ‘Candidatus Rickettsia andeanae’ and Probable Exclusion of Rickettsia parkeri in Ticks from Dogs in a Natural Area of the Pampa Biome in Brazil
title_short ‘Candidatus Rickettsia andeanae’ and Probable Exclusion of Rickettsia parkeri in Ticks from Dogs in a Natural Area of the Pampa Biome in Brazil
title_sort ‘candidatus rickettsia andeanae’ and probable exclusion of rickettsia parkeri in ticks from dogs in a natural area of the pampa biome in brazil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054268/
https://www.ncbi.nlm.nih.gov/pubmed/36986368
http://dx.doi.org/10.3390/pathogens12030446
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