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Evaluation of Kidney Donor Risk Index/Kidney Donor Profile Index as Predictor Tools of Deceased-Donor Kidney Transplant Outcomes in a Greek Cohort

The Kidney Donor Risk Index (KDRI) and Kidney Donor Profile Index (KDPI) have been developed to assess deceased-donor graft quality, although validation of their utility outside the USA remains limited. This single-center retrospective cohort study evaluated the ability of KDRI and KDPI to predict t...

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Autores principales: Darema, Maria, Athanasopoulou, Diamanto, Bellos, Ioannis, Tsoumbou, Ioanna, Vittoraki, Angeliki G., Bokos, John, Marinaki, Smaragdi, Boletis, Ioannis N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054426/
https://www.ncbi.nlm.nih.gov/pubmed/36983440
http://dx.doi.org/10.3390/jcm12062439
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author Darema, Maria
Athanasopoulou, Diamanto
Bellos, Ioannis
Tsoumbou, Ioanna
Vittoraki, Angeliki G.
Bokos, John
Marinaki, Smaragdi
Boletis, Ioannis N.
author_facet Darema, Maria
Athanasopoulou, Diamanto
Bellos, Ioannis
Tsoumbou, Ioanna
Vittoraki, Angeliki G.
Bokos, John
Marinaki, Smaragdi
Boletis, Ioannis N.
author_sort Darema, Maria
collection PubMed
description The Kidney Donor Risk Index (KDRI) and Kidney Donor Profile Index (KDPI) have been developed to assess deceased-donor graft quality, although validation of their utility outside the USA remains limited. This single-center retrospective cohort study evaluated the ability of KDRI and KDPI to predict transplant outcomes in a Greek cohort. The efficacy of KDRI, KDPI, and donor’s age in predicting death-censored graft failure was primarily assessed. Overall, 394 donors and 456 recipients were included. Death-censored graft survival was significantly worse with increasing KDRI (hazard ratio—HR: 2.21, 95% confidence intervals—CI: 1.16–4.22), KDPI (HR: 1.01, 95% CI: 1.00–1.02), and donor’s age (HR: 1.03, 95% CI: 1.00–1.05). The unadjusted discriminative ability was similar for KDPI (C-statistic: 0.54) and donor’s age (C-statistic: 0.52). The KDPI threshold of 85 was not predictive of graft failure (p-value: 0.19). Higher KDPI was linked to delayed graft function and worse kidney function, but not among expanded-criteria donor transplantations. No significant association was found between KDRI, KDPI, and patient survival. In conclusion, increasing KDRI and KDPI are linked to worse graft function, although their ability to discriminate long-term graft failure remains limited.
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spelling pubmed-100544262023-03-30 Evaluation of Kidney Donor Risk Index/Kidney Donor Profile Index as Predictor Tools of Deceased-Donor Kidney Transplant Outcomes in a Greek Cohort Darema, Maria Athanasopoulou, Diamanto Bellos, Ioannis Tsoumbou, Ioanna Vittoraki, Angeliki G. Bokos, John Marinaki, Smaragdi Boletis, Ioannis N. J Clin Med Article The Kidney Donor Risk Index (KDRI) and Kidney Donor Profile Index (KDPI) have been developed to assess deceased-donor graft quality, although validation of their utility outside the USA remains limited. This single-center retrospective cohort study evaluated the ability of KDRI and KDPI to predict transplant outcomes in a Greek cohort. The efficacy of KDRI, KDPI, and donor’s age in predicting death-censored graft failure was primarily assessed. Overall, 394 donors and 456 recipients were included. Death-censored graft survival was significantly worse with increasing KDRI (hazard ratio—HR: 2.21, 95% confidence intervals—CI: 1.16–4.22), KDPI (HR: 1.01, 95% CI: 1.00–1.02), and donor’s age (HR: 1.03, 95% CI: 1.00–1.05). The unadjusted discriminative ability was similar for KDPI (C-statistic: 0.54) and donor’s age (C-statistic: 0.52). The KDPI threshold of 85 was not predictive of graft failure (p-value: 0.19). Higher KDPI was linked to delayed graft function and worse kidney function, but not among expanded-criteria donor transplantations. No significant association was found between KDRI, KDPI, and patient survival. In conclusion, increasing KDRI and KDPI are linked to worse graft function, although their ability to discriminate long-term graft failure remains limited. MDPI 2023-03-22 /pmc/articles/PMC10054426/ /pubmed/36983440 http://dx.doi.org/10.3390/jcm12062439 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Darema, Maria
Athanasopoulou, Diamanto
Bellos, Ioannis
Tsoumbou, Ioanna
Vittoraki, Angeliki G.
Bokos, John
Marinaki, Smaragdi
Boletis, Ioannis N.
Evaluation of Kidney Donor Risk Index/Kidney Donor Profile Index as Predictor Tools of Deceased-Donor Kidney Transplant Outcomes in a Greek Cohort
title Evaluation of Kidney Donor Risk Index/Kidney Donor Profile Index as Predictor Tools of Deceased-Donor Kidney Transplant Outcomes in a Greek Cohort
title_full Evaluation of Kidney Donor Risk Index/Kidney Donor Profile Index as Predictor Tools of Deceased-Donor Kidney Transplant Outcomes in a Greek Cohort
title_fullStr Evaluation of Kidney Donor Risk Index/Kidney Donor Profile Index as Predictor Tools of Deceased-Donor Kidney Transplant Outcomes in a Greek Cohort
title_full_unstemmed Evaluation of Kidney Donor Risk Index/Kidney Donor Profile Index as Predictor Tools of Deceased-Donor Kidney Transplant Outcomes in a Greek Cohort
title_short Evaluation of Kidney Donor Risk Index/Kidney Donor Profile Index as Predictor Tools of Deceased-Donor Kidney Transplant Outcomes in a Greek Cohort
title_sort evaluation of kidney donor risk index/kidney donor profile index as predictor tools of deceased-donor kidney transplant outcomes in a greek cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054426/
https://www.ncbi.nlm.nih.gov/pubmed/36983440
http://dx.doi.org/10.3390/jcm12062439
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