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The Prognostic Role of Spot Urinary Sodium and Chloride in a Cohort of Hospitalized Advanced Heart Failure Patients: A Pilot Study

Recent studies have demonstrated the prognostic value of spot urinary sodium (UNa(+)) in acutely decompensated chronic HF (ADCHF) patients. However, data on the prognostic role of UNa(+) and spot urinary chloride (UCl(−)) in patients with advanced HF are limited. In the present prospective pilot stu...

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Autores principales: Xanthopoulos, Andrew, Christofidis, Charalambos, Pantsios, Chris, Magouliotis, Dimitrios, Bourazana, Angeliki, Leventis, Ioannis, Skopeliti, Niki, Skoularigki, Evangelia, Briasoulis, Alexandros, Giamouzis, Grigorios, Triposkiadis, Filippos, Skoularigis, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054455/
https://www.ncbi.nlm.nih.gov/pubmed/36983853
http://dx.doi.org/10.3390/life13030698
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author Xanthopoulos, Andrew
Christofidis, Charalambos
Pantsios, Chris
Magouliotis, Dimitrios
Bourazana, Angeliki
Leventis, Ioannis
Skopeliti, Niki
Skoularigki, Evangelia
Briasoulis, Alexandros
Giamouzis, Grigorios
Triposkiadis, Filippos
Skoularigis, John
author_facet Xanthopoulos, Andrew
Christofidis, Charalambos
Pantsios, Chris
Magouliotis, Dimitrios
Bourazana, Angeliki
Leventis, Ioannis
Skopeliti, Niki
Skoularigki, Evangelia
Briasoulis, Alexandros
Giamouzis, Grigorios
Triposkiadis, Filippos
Skoularigis, John
author_sort Xanthopoulos, Andrew
collection PubMed
description Recent studies have demonstrated the prognostic value of spot urinary sodium (UNa(+)) in acutely decompensated chronic HF (ADCHF) patients. However, data on the prognostic role of UNa(+) and spot urinary chloride (UCl(−)) in patients with advanced HF are limited. In the present prospective pilot study, we examined the predictive value of UNa(+) and UCl(−) concentration at baseline, at 2 h and at 24 h after admission for all-cause mortality and HF rehospitalization up to 3 months post-discharge. Consecutive advanced HF patients (n = 30) admitted with ADCHF and aged > 18 years were included in the study. Loop diuretics were administered based on the natriuresis-guided algorithm recommended by the recent HF guidelines. Exclusion criteria were cardiogenic shock, acute coronary syndrome, estimated glomerular filtration rate < 15 mL/min/1.73 m(2), severe hepatic dysfunction (Child–Pugh category C), and sepsis. UNa(+) at baseline (Area Under the Curve (AUC) = 0.75, 95% Confidence Interval (CI) (0.58–0.93), p = 0.019) and at 2 h after admission (AUC = 0.80, 95% CI: 0.64–0.96, p = 0.005) showed good and excellent discrimination, respectively. UCl(−) at 2 h after admission (AUC = 0.75, 95%CI (0.57–0.93), p = 0.017) demonstrated good discrimination. In the multivariate logistic regression analysis, UNa(+) at 2 h (p = 0.02) and dose of loop diuretics at admission (p = 0.03) were the only factors independently associated with the study outcome. In conclusion, UNa(+) and UCl(−) may have a prognostic role in hospitalized advanced HF patients.
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spelling pubmed-100544552023-03-30 The Prognostic Role of Spot Urinary Sodium and Chloride in a Cohort of Hospitalized Advanced Heart Failure Patients: A Pilot Study Xanthopoulos, Andrew Christofidis, Charalambos Pantsios, Chris Magouliotis, Dimitrios Bourazana, Angeliki Leventis, Ioannis Skopeliti, Niki Skoularigki, Evangelia Briasoulis, Alexandros Giamouzis, Grigorios Triposkiadis, Filippos Skoularigis, John Life (Basel) Article Recent studies have demonstrated the prognostic value of spot urinary sodium (UNa(+)) in acutely decompensated chronic HF (ADCHF) patients. However, data on the prognostic role of UNa(+) and spot urinary chloride (UCl(−)) in patients with advanced HF are limited. In the present prospective pilot study, we examined the predictive value of UNa(+) and UCl(−) concentration at baseline, at 2 h and at 24 h after admission for all-cause mortality and HF rehospitalization up to 3 months post-discharge. Consecutive advanced HF patients (n = 30) admitted with ADCHF and aged > 18 years were included in the study. Loop diuretics were administered based on the natriuresis-guided algorithm recommended by the recent HF guidelines. Exclusion criteria were cardiogenic shock, acute coronary syndrome, estimated glomerular filtration rate < 15 mL/min/1.73 m(2), severe hepatic dysfunction (Child–Pugh category C), and sepsis. UNa(+) at baseline (Area Under the Curve (AUC) = 0.75, 95% Confidence Interval (CI) (0.58–0.93), p = 0.019) and at 2 h after admission (AUC = 0.80, 95% CI: 0.64–0.96, p = 0.005) showed good and excellent discrimination, respectively. UCl(−) at 2 h after admission (AUC = 0.75, 95%CI (0.57–0.93), p = 0.017) demonstrated good discrimination. In the multivariate logistic regression analysis, UNa(+) at 2 h (p = 0.02) and dose of loop diuretics at admission (p = 0.03) were the only factors independently associated with the study outcome. In conclusion, UNa(+) and UCl(−) may have a prognostic role in hospitalized advanced HF patients. MDPI 2023-03-05 /pmc/articles/PMC10054455/ /pubmed/36983853 http://dx.doi.org/10.3390/life13030698 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xanthopoulos, Andrew
Christofidis, Charalambos
Pantsios, Chris
Magouliotis, Dimitrios
Bourazana, Angeliki
Leventis, Ioannis
Skopeliti, Niki
Skoularigki, Evangelia
Briasoulis, Alexandros
Giamouzis, Grigorios
Triposkiadis, Filippos
Skoularigis, John
The Prognostic Role of Spot Urinary Sodium and Chloride in a Cohort of Hospitalized Advanced Heart Failure Patients: A Pilot Study
title The Prognostic Role of Spot Urinary Sodium and Chloride in a Cohort of Hospitalized Advanced Heart Failure Patients: A Pilot Study
title_full The Prognostic Role of Spot Urinary Sodium and Chloride in a Cohort of Hospitalized Advanced Heart Failure Patients: A Pilot Study
title_fullStr The Prognostic Role of Spot Urinary Sodium and Chloride in a Cohort of Hospitalized Advanced Heart Failure Patients: A Pilot Study
title_full_unstemmed The Prognostic Role of Spot Urinary Sodium and Chloride in a Cohort of Hospitalized Advanced Heart Failure Patients: A Pilot Study
title_short The Prognostic Role of Spot Urinary Sodium and Chloride in a Cohort of Hospitalized Advanced Heart Failure Patients: A Pilot Study
title_sort prognostic role of spot urinary sodium and chloride in a cohort of hospitalized advanced heart failure patients: a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054455/
https://www.ncbi.nlm.nih.gov/pubmed/36983853
http://dx.doi.org/10.3390/life13030698
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