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Metabolic-Dysfunction-Associated Fatty Liver Disease and Gut Microbiota: From Fatty Liver to Dysmetabolic Syndrome

Metabolic-dysfunction-associated fatty liver disease (MAFLD) is the recent nomenclature designation that associates the condition of non-alcoholic fatty liver disease (NAFLD) with metabolic dysfunction. Its diagnosis has been debated in the recent period and is generally associated with a diagnosis...

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Autores principales: Abenavoli, Ludovico, Scarlata, Giuseppe Guido Maria, Scarpellini, Emidio, Boccuto, Luigi, Spagnuolo, Rocco, Tilocca, Bruno, Roncada, Paola, Luzza, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054528/
https://www.ncbi.nlm.nih.gov/pubmed/36984595
http://dx.doi.org/10.3390/medicina59030594
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author Abenavoli, Ludovico
Scarlata, Giuseppe Guido Maria
Scarpellini, Emidio
Boccuto, Luigi
Spagnuolo, Rocco
Tilocca, Bruno
Roncada, Paola
Luzza, Francesco
author_facet Abenavoli, Ludovico
Scarlata, Giuseppe Guido Maria
Scarpellini, Emidio
Boccuto, Luigi
Spagnuolo, Rocco
Tilocca, Bruno
Roncada, Paola
Luzza, Francesco
author_sort Abenavoli, Ludovico
collection PubMed
description Metabolic-dysfunction-associated fatty liver disease (MAFLD) is the recent nomenclature designation that associates the condition of non-alcoholic fatty liver disease (NAFLD) with metabolic dysfunction. Its diagnosis has been debated in the recent period and is generally associated with a diagnosis of steatosis and at least one pathologic condition among overweight/obesity, type 2 diabetes mellitus, and metabolic dysregulation. Its pathogenesis is defined by a “multiple-hit” model and is associated with alteration or dysbiosis of the gut microbiota. The pathogenic role of dysbiosis of the gut microbiota has been investigated in many diseases, including obesity, type 2 diabetes mellitus, and NAFLD. However, only a few works correlate it with MAFLD, although common pathogenetic links to these diseases are suspected. This review underlines the most recurrent changes in the gut microbiota of patients with MAFLD, while also evidencing possible pathogenetic links.
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spelling pubmed-100545282023-03-30 Metabolic-Dysfunction-Associated Fatty Liver Disease and Gut Microbiota: From Fatty Liver to Dysmetabolic Syndrome Abenavoli, Ludovico Scarlata, Giuseppe Guido Maria Scarpellini, Emidio Boccuto, Luigi Spagnuolo, Rocco Tilocca, Bruno Roncada, Paola Luzza, Francesco Medicina (Kaunas) Review Metabolic-dysfunction-associated fatty liver disease (MAFLD) is the recent nomenclature designation that associates the condition of non-alcoholic fatty liver disease (NAFLD) with metabolic dysfunction. Its diagnosis has been debated in the recent period and is generally associated with a diagnosis of steatosis and at least one pathologic condition among overweight/obesity, type 2 diabetes mellitus, and metabolic dysregulation. Its pathogenesis is defined by a “multiple-hit” model and is associated with alteration or dysbiosis of the gut microbiota. The pathogenic role of dysbiosis of the gut microbiota has been investigated in many diseases, including obesity, type 2 diabetes mellitus, and NAFLD. However, only a few works correlate it with MAFLD, although common pathogenetic links to these diseases are suspected. This review underlines the most recurrent changes in the gut microbiota of patients with MAFLD, while also evidencing possible pathogenetic links. MDPI 2023-03-17 /pmc/articles/PMC10054528/ /pubmed/36984595 http://dx.doi.org/10.3390/medicina59030594 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Abenavoli, Ludovico
Scarlata, Giuseppe Guido Maria
Scarpellini, Emidio
Boccuto, Luigi
Spagnuolo, Rocco
Tilocca, Bruno
Roncada, Paola
Luzza, Francesco
Metabolic-Dysfunction-Associated Fatty Liver Disease and Gut Microbiota: From Fatty Liver to Dysmetabolic Syndrome
title Metabolic-Dysfunction-Associated Fatty Liver Disease and Gut Microbiota: From Fatty Liver to Dysmetabolic Syndrome
title_full Metabolic-Dysfunction-Associated Fatty Liver Disease and Gut Microbiota: From Fatty Liver to Dysmetabolic Syndrome
title_fullStr Metabolic-Dysfunction-Associated Fatty Liver Disease and Gut Microbiota: From Fatty Liver to Dysmetabolic Syndrome
title_full_unstemmed Metabolic-Dysfunction-Associated Fatty Liver Disease and Gut Microbiota: From Fatty Liver to Dysmetabolic Syndrome
title_short Metabolic-Dysfunction-Associated Fatty Liver Disease and Gut Microbiota: From Fatty Liver to Dysmetabolic Syndrome
title_sort metabolic-dysfunction-associated fatty liver disease and gut microbiota: from fatty liver to dysmetabolic syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054528/
https://www.ncbi.nlm.nih.gov/pubmed/36984595
http://dx.doi.org/10.3390/medicina59030594
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