VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis

Clinical sequencing efforts are rapidly identifying sarcoma gene fusions that lack functional validation. An example is the fusion of transcriptional coactivators, VGLL2-NCOA2, found in infantile rhabdomyosarcoma. To delineate VGLL2-NCOA2 tumorigenic mechanisms and identify therapeutic vulnerabiliti...

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Detalles Bibliográficos
Autores principales: Watson, Sarah, LaVigne, Collette A., Xu, Lin, Surdez, Didier, Cyrta, Joanna, Calderon, Delia, Cannon, Matthew V., Kent, Matthew R., Silvius, Katherine M., Kucinski, Jack P., Harrison, Emma N., Murchison, Whitney, Dinesh Rakheja, Tirode, Franck, Delattre, Olivier, Amatruda, James F., Kendall, Genevieve C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054615/
https://www.ncbi.nlm.nih.gov/pubmed/36656711
http://dx.doi.org/10.1016/j.celrep.2023.112013

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