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Green Tea and Benign Gynecologic Disorders: A New Trick for An Old Beverage?

Green tea is harvested from the tea plant Camellia sinensis and is one of the most widely consumed beverages worldwide. It is richer in antioxidants than other forms of tea and has a uniquely high content of polyphenolic compounds known as catechins. Epigallocatechin-3-gallate (EGCG), the major gree...

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Autores principales: Hazimeh, Dana, Massoud, Gaelle, Parish, Maclaine, Singh, Bhuchitra, Segars, James, Islam, Md Soriful
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054707/
https://www.ncbi.nlm.nih.gov/pubmed/36986169
http://dx.doi.org/10.3390/nu15061439
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author Hazimeh, Dana
Massoud, Gaelle
Parish, Maclaine
Singh, Bhuchitra
Segars, James
Islam, Md Soriful
author_facet Hazimeh, Dana
Massoud, Gaelle
Parish, Maclaine
Singh, Bhuchitra
Segars, James
Islam, Md Soriful
author_sort Hazimeh, Dana
collection PubMed
description Green tea is harvested from the tea plant Camellia sinensis and is one of the most widely consumed beverages worldwide. It is richer in antioxidants than other forms of tea and has a uniquely high content of polyphenolic compounds known as catechins. Epigallocatechin-3-gallate (EGCG), the major green tea catechin, has been studied for its potential therapeutic role in many disease contexts, including pathologies of the female reproductive system. As both a prooxidant and antioxidant, EGCG can modulate many cellular pathways important to disease pathogenesis and thus has clinical benefits. This review provides a synopsis of the current knowledge on the beneficial effects of green tea in benign gynecological disorders. Green tea alleviates symptom severity in uterine fibroids and improves endometriosis through anti-fibrotic, anti-angiogenic, and pro-apoptotic mechanisms. Additionally, it can reduce uterine contractility and improve the generalized hyperalgesia associated with dysmenorrhea and adenomyosis. Although its role in infertility is controversial, EGCG can be used as a symptomatic treatment for menopause, where it decreases weight gain and osteoporosis, as well as for polycystic ovary syndrome (PCOS).
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spelling pubmed-100547072023-03-30 Green Tea and Benign Gynecologic Disorders: A New Trick for An Old Beverage? Hazimeh, Dana Massoud, Gaelle Parish, Maclaine Singh, Bhuchitra Segars, James Islam, Md Soriful Nutrients Review Green tea is harvested from the tea plant Camellia sinensis and is one of the most widely consumed beverages worldwide. It is richer in antioxidants than other forms of tea and has a uniquely high content of polyphenolic compounds known as catechins. Epigallocatechin-3-gallate (EGCG), the major green tea catechin, has been studied for its potential therapeutic role in many disease contexts, including pathologies of the female reproductive system. As both a prooxidant and antioxidant, EGCG can modulate many cellular pathways important to disease pathogenesis and thus has clinical benefits. This review provides a synopsis of the current knowledge on the beneficial effects of green tea in benign gynecological disorders. Green tea alleviates symptom severity in uterine fibroids and improves endometriosis through anti-fibrotic, anti-angiogenic, and pro-apoptotic mechanisms. Additionally, it can reduce uterine contractility and improve the generalized hyperalgesia associated with dysmenorrhea and adenomyosis. Although its role in infertility is controversial, EGCG can be used as a symptomatic treatment for menopause, where it decreases weight gain and osteoporosis, as well as for polycystic ovary syndrome (PCOS). MDPI 2023-03-16 /pmc/articles/PMC10054707/ /pubmed/36986169 http://dx.doi.org/10.3390/nu15061439 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hazimeh, Dana
Massoud, Gaelle
Parish, Maclaine
Singh, Bhuchitra
Segars, James
Islam, Md Soriful
Green Tea and Benign Gynecologic Disorders: A New Trick for An Old Beverage?
title Green Tea and Benign Gynecologic Disorders: A New Trick for An Old Beverage?
title_full Green Tea and Benign Gynecologic Disorders: A New Trick for An Old Beverage?
title_fullStr Green Tea and Benign Gynecologic Disorders: A New Trick for An Old Beverage?
title_full_unstemmed Green Tea and Benign Gynecologic Disorders: A New Trick for An Old Beverage?
title_short Green Tea and Benign Gynecologic Disorders: A New Trick for An Old Beverage?
title_sort green tea and benign gynecologic disorders: a new trick for an old beverage?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054707/
https://www.ncbi.nlm.nih.gov/pubmed/36986169
http://dx.doi.org/10.3390/nu15061439
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