A Simple and Easily Implemented Method for the Regioselective Introduction of Deuterium into Azolo[1,5-a]pyrimidines Molecules

A method for the technically easy-to-implement synthesis of deuterium-labeled pyrazolo[1,5-a]pyrimidines and 1,2,4-triazolo[1,5-a]pyrimidines have been developed. The regioselectivity of such transformations has been shown. (1)H NMR and mass spectrometric methods have proved the quantitative nature...

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Autores principales: Danagulyan, Gevorg G., Panosyan, Henrik A., Gharibyan, Vache K., Hasratyan, Ani H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054722/
https://www.ncbi.nlm.nih.gov/pubmed/36985841
http://dx.doi.org/10.3390/molecules28062869
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author Danagulyan, Gevorg G.
Panosyan, Henrik A.
Gharibyan, Vache K.
Hasratyan, Ani H.
author_facet Danagulyan, Gevorg G.
Panosyan, Henrik A.
Gharibyan, Vache K.
Hasratyan, Ani H.
author_sort Danagulyan, Gevorg G.
collection PubMed
description A method for the technically easy-to-implement synthesis of deuterium-labeled pyrazolo[1,5-a]pyrimidines and 1,2,4-triazolo[1,5-a]pyrimidines have been developed. The regioselectivity of such transformations has been shown. (1)H NMR and mass spectrometric methods have proved the quantitative nature of such transformations and the kinetics of deuterium exchange has been studied. Spectrally, at different temperatures (+30 °C, −10 °C and −15 °C), the kinetics of the process was studied both in CD(3)OD and in deuterated alkali.
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spelling pubmed-100547222023-03-30 A Simple and Easily Implemented Method for the Regioselective Introduction of Deuterium into Azolo[1,5-a]pyrimidines Molecules Danagulyan, Gevorg G. Panosyan, Henrik A. Gharibyan, Vache K. Hasratyan, Ani H. Molecules Article A method for the technically easy-to-implement synthesis of deuterium-labeled pyrazolo[1,5-a]pyrimidines and 1,2,4-triazolo[1,5-a]pyrimidines have been developed. The regioselectivity of such transformations has been shown. (1)H NMR and mass spectrometric methods have proved the quantitative nature of such transformations and the kinetics of deuterium exchange has been studied. Spectrally, at different temperatures (+30 °C, −10 °C and −15 °C), the kinetics of the process was studied both in CD(3)OD and in deuterated alkali. MDPI 2023-03-22 /pmc/articles/PMC10054722/ /pubmed/36985841 http://dx.doi.org/10.3390/molecules28062869 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Danagulyan, Gevorg G.
Panosyan, Henrik A.
Gharibyan, Vache K.
Hasratyan, Ani H.
A Simple and Easily Implemented Method for the Regioselective Introduction of Deuterium into Azolo[1,5-a]pyrimidines Molecules
title A Simple and Easily Implemented Method for the Regioselective Introduction of Deuterium into Azolo[1,5-a]pyrimidines Molecules
title_full A Simple and Easily Implemented Method for the Regioselective Introduction of Deuterium into Azolo[1,5-a]pyrimidines Molecules
title_fullStr A Simple and Easily Implemented Method for the Regioselective Introduction of Deuterium into Azolo[1,5-a]pyrimidines Molecules
title_full_unstemmed A Simple and Easily Implemented Method for the Regioselective Introduction of Deuterium into Azolo[1,5-a]pyrimidines Molecules
title_short A Simple and Easily Implemented Method for the Regioselective Introduction of Deuterium into Azolo[1,5-a]pyrimidines Molecules
title_sort simple and easily implemented method for the regioselective introduction of deuterium into azolo[1,5-a]pyrimidines molecules
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054722/
https://www.ncbi.nlm.nih.gov/pubmed/36985841
http://dx.doi.org/10.3390/molecules28062869
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