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Biogenic Preparation and Characterization of Silver Nanoparticles from Seed Kernel of Mangifera indica and Their Antibacterial Potential against Shigella spp.

Shigellosis is a serious foodborne diarrheal disease caused by the Shigella species. It is a critical global health issue. In developing countries, shigellosis causes most of the mortality in children below 5 years of age. Globally, around 165 million cases of diarrhea caused by Shigella are reporte...

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Autores principales: Angamuthu, Sudha, Thangaswamy, Selvankumar, Raju, Amutha, Husain, Fohad Mabood, Ahmed, Bilal, Al-Shabib, Nasser A., Hakeem, Mohammed Jamal, Shahzad, Syed Ali, Abudujayn, Saud A., Alomar, Suliman Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054846/
https://www.ncbi.nlm.nih.gov/pubmed/36985439
http://dx.doi.org/10.3390/molecules28062468
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author Angamuthu, Sudha
Thangaswamy, Selvankumar
Raju, Amutha
Husain, Fohad Mabood
Ahmed, Bilal
Al-Shabib, Nasser A.
Hakeem, Mohammed Jamal
Shahzad, Syed Ali
Abudujayn, Saud A.
Alomar, Suliman Y.
author_facet Angamuthu, Sudha
Thangaswamy, Selvankumar
Raju, Amutha
Husain, Fohad Mabood
Ahmed, Bilal
Al-Shabib, Nasser A.
Hakeem, Mohammed Jamal
Shahzad, Syed Ali
Abudujayn, Saud A.
Alomar, Suliman Y.
author_sort Angamuthu, Sudha
collection PubMed
description Shigellosis is a serious foodborne diarrheal disease caused by the Shigella species. It is a critical global health issue. In developing countries, shigellosis causes most of the mortality in children below 5 years of age. Globally, around 165 million cases of diarrhea caused by Shigella are reported, which accounts for almost 1 million deaths, in which the majority are recorded in Third World nations. In this study, silver nanoparticles were synthesized using Mangifera indica kernel (MK-AgNPs) seed extracts. The biosynthesized M. indica silver nanoparticles (MK-AgNPs) were characterized using an array of spectroscopic and microscopic tools, such as UV–Vis, scanning electron microscopy, particle size analyzer, Fourier transform infrared spectroscopy, and X-ray diffractometer. The nanoparticles were spherical in shape and the average size was found to be 42.7 nm. The MK-AgNPs exhibited remarkable antibacterial activity against antibiotic-resistant clinical Shigella sp. The minimum inhibitory concentration (MIC) value of the MK-AgNPs was found to be 20 μg/mL against the multi-drug-resistant strain Shigella flexneri. The results clearly demonstrate that MK-AgNPs prepared using M. indica kernel seed extract exhibited significant bactericidal action against pathogenic Shigella species. The biosynthesized nanoparticles from mango kernel could possibly prove therapeutically useful and effective in combating the threat of shigellosis after careful investigation of its toxicity and in vivo efficacy.
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spelling pubmed-100548462023-03-30 Biogenic Preparation and Characterization of Silver Nanoparticles from Seed Kernel of Mangifera indica and Their Antibacterial Potential against Shigella spp. Angamuthu, Sudha Thangaswamy, Selvankumar Raju, Amutha Husain, Fohad Mabood Ahmed, Bilal Al-Shabib, Nasser A. Hakeem, Mohammed Jamal Shahzad, Syed Ali Abudujayn, Saud A. Alomar, Suliman Y. Molecules Article Shigellosis is a serious foodborne diarrheal disease caused by the Shigella species. It is a critical global health issue. In developing countries, shigellosis causes most of the mortality in children below 5 years of age. Globally, around 165 million cases of diarrhea caused by Shigella are reported, which accounts for almost 1 million deaths, in which the majority are recorded in Third World nations. In this study, silver nanoparticles were synthesized using Mangifera indica kernel (MK-AgNPs) seed extracts. The biosynthesized M. indica silver nanoparticles (MK-AgNPs) were characterized using an array of spectroscopic and microscopic tools, such as UV–Vis, scanning electron microscopy, particle size analyzer, Fourier transform infrared spectroscopy, and X-ray diffractometer. The nanoparticles were spherical in shape and the average size was found to be 42.7 nm. The MK-AgNPs exhibited remarkable antibacterial activity against antibiotic-resistant clinical Shigella sp. The minimum inhibitory concentration (MIC) value of the MK-AgNPs was found to be 20 μg/mL against the multi-drug-resistant strain Shigella flexneri. The results clearly demonstrate that MK-AgNPs prepared using M. indica kernel seed extract exhibited significant bactericidal action against pathogenic Shigella species. The biosynthesized nanoparticles from mango kernel could possibly prove therapeutically useful and effective in combating the threat of shigellosis after careful investigation of its toxicity and in vivo efficacy. MDPI 2023-03-08 /pmc/articles/PMC10054846/ /pubmed/36985439 http://dx.doi.org/10.3390/molecules28062468 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Angamuthu, Sudha
Thangaswamy, Selvankumar
Raju, Amutha
Husain, Fohad Mabood
Ahmed, Bilal
Al-Shabib, Nasser A.
Hakeem, Mohammed Jamal
Shahzad, Syed Ali
Abudujayn, Saud A.
Alomar, Suliman Y.
Biogenic Preparation and Characterization of Silver Nanoparticles from Seed Kernel of Mangifera indica and Their Antibacterial Potential against Shigella spp.
title Biogenic Preparation and Characterization of Silver Nanoparticles from Seed Kernel of Mangifera indica and Their Antibacterial Potential against Shigella spp.
title_full Biogenic Preparation and Characterization of Silver Nanoparticles from Seed Kernel of Mangifera indica and Their Antibacterial Potential against Shigella spp.
title_fullStr Biogenic Preparation and Characterization of Silver Nanoparticles from Seed Kernel of Mangifera indica and Their Antibacterial Potential against Shigella spp.
title_full_unstemmed Biogenic Preparation and Characterization of Silver Nanoparticles from Seed Kernel of Mangifera indica and Their Antibacterial Potential against Shigella spp.
title_short Biogenic Preparation and Characterization of Silver Nanoparticles from Seed Kernel of Mangifera indica and Their Antibacterial Potential against Shigella spp.
title_sort biogenic preparation and characterization of silver nanoparticles from seed kernel of mangifera indica and their antibacterial potential against shigella spp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054846/
https://www.ncbi.nlm.nih.gov/pubmed/36985439
http://dx.doi.org/10.3390/molecules28062468
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