New Isocoumarins from the Marine Fungus Phaeosphaeriopsis sp. WP-26

Five new isocoumarins, phaeosphaerins A–E (1–5), were isolated from the fermentation broth of the marine fungus Phaeosphaeriopsis sp. WP-26, along with one known isocoumarin, 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (6), and two known pimarane-type diterpenes, diaportheins A (7) and B (8). Their...

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Autores principales: Wang, Pei, Wang, Huifang, Yang, Juchun, Yang, Li, Cai, Caihong, Yuan, Jingzhe, Wu, Fei, Gai, Cuijuan, Mei, Wenli, Dai, Haofu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054857/
https://www.ncbi.nlm.nih.gov/pubmed/36976199
http://dx.doi.org/10.3390/md21030150
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author Wang, Pei
Wang, Huifang
Yang, Juchun
Yang, Li
Cai, Caihong
Yuan, Jingzhe
Wu, Fei
Gai, Cuijuan
Mei, Wenli
Dai, Haofu
author_facet Wang, Pei
Wang, Huifang
Yang, Juchun
Yang, Li
Cai, Caihong
Yuan, Jingzhe
Wu, Fei
Gai, Cuijuan
Mei, Wenli
Dai, Haofu
author_sort Wang, Pei
collection PubMed
description Five new isocoumarins, phaeosphaerins A–E (1–5), were isolated from the fermentation broth of the marine fungus Phaeosphaeriopsis sp. WP-26, along with one known isocoumarin, 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (6), and two known pimarane-type diterpenes, diaportheins A (7) and B (8). Their structures were elucidated via NMR experiments, X-ray diffraction analysis, and comparison of the experimental and computed ECD curves. Compounds 1–7 displayed weak neuroprotective effects against H(2)O(2)-induced damage in SH-SY5Y cells. Moreover, compound 8 showed cytotoxicity against BEL-7402, SGC-7901, K562, A549, and HL-60 cell lines.
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spelling pubmed-100548572023-03-30 New Isocoumarins from the Marine Fungus Phaeosphaeriopsis sp. WP-26 Wang, Pei Wang, Huifang Yang, Juchun Yang, Li Cai, Caihong Yuan, Jingzhe Wu, Fei Gai, Cuijuan Mei, Wenli Dai, Haofu Mar Drugs Article Five new isocoumarins, phaeosphaerins A–E (1–5), were isolated from the fermentation broth of the marine fungus Phaeosphaeriopsis sp. WP-26, along with one known isocoumarin, 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (6), and two known pimarane-type diterpenes, diaportheins A (7) and B (8). Their structures were elucidated via NMR experiments, X-ray diffraction analysis, and comparison of the experimental and computed ECD curves. Compounds 1–7 displayed weak neuroprotective effects against H(2)O(2)-induced damage in SH-SY5Y cells. Moreover, compound 8 showed cytotoxicity against BEL-7402, SGC-7901, K562, A549, and HL-60 cell lines. MDPI 2023-02-25 /pmc/articles/PMC10054857/ /pubmed/36976199 http://dx.doi.org/10.3390/md21030150 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Pei
Wang, Huifang
Yang, Juchun
Yang, Li
Cai, Caihong
Yuan, Jingzhe
Wu, Fei
Gai, Cuijuan
Mei, Wenli
Dai, Haofu
New Isocoumarins from the Marine Fungus Phaeosphaeriopsis sp. WP-26
title New Isocoumarins from the Marine Fungus Phaeosphaeriopsis sp. WP-26
title_full New Isocoumarins from the Marine Fungus Phaeosphaeriopsis sp. WP-26
title_fullStr New Isocoumarins from the Marine Fungus Phaeosphaeriopsis sp. WP-26
title_full_unstemmed New Isocoumarins from the Marine Fungus Phaeosphaeriopsis sp. WP-26
title_short New Isocoumarins from the Marine Fungus Phaeosphaeriopsis sp. WP-26
title_sort new isocoumarins from the marine fungus phaeosphaeriopsis sp. wp-26
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054857/
https://www.ncbi.nlm.nih.gov/pubmed/36976199
http://dx.doi.org/10.3390/md21030150
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