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Infections in DNA Repair Defects

DNA repair defects are heterogenous conditions characterized by a wide spectrum of clinical phenotypes. The common presentations of DNA repair defects include increased risk of cancer, accelerated aging, and defects in the development of various organs and systems. The immune system can be affected...

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Detalles Bibliográficos
Autores principales: Yilmaz Demirdag, Yesim, Gupta, Sudhir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054915/
https://www.ncbi.nlm.nih.gov/pubmed/36986362
http://dx.doi.org/10.3390/pathogens12030440
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author Yilmaz Demirdag, Yesim
Gupta, Sudhir
author_facet Yilmaz Demirdag, Yesim
Gupta, Sudhir
author_sort Yilmaz Demirdag, Yesim
collection PubMed
description DNA repair defects are heterogenous conditions characterized by a wide spectrum of clinical phenotypes. The common presentations of DNA repair defects include increased risk of cancer, accelerated aging, and defects in the development of various organs and systems. The immune system can be affected in a subset of these disorders leading to susceptibility to infections and autoimmunity. Infections in DNA repair defects may occur due to primary defects in T, B, or NK cells and other factors such as anatomic defects, neurologic disorders, or during chemotherapy. Consequently, the characteristics of the infections may vary from mild upper respiratory tract infections to severe, opportunistic, and even fatal infections with bacteria, viruses, or fungi. Here, infections in 15 rare and sporadic DNA repair defects that are associated with immunodeficiencies are discussed. Because of the rarity of some of these conditions, limited information is available regarding infectious complications.
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spelling pubmed-100549152023-03-30 Infections in DNA Repair Defects Yilmaz Demirdag, Yesim Gupta, Sudhir Pathogens Review DNA repair defects are heterogenous conditions characterized by a wide spectrum of clinical phenotypes. The common presentations of DNA repair defects include increased risk of cancer, accelerated aging, and defects in the development of various organs and systems. The immune system can be affected in a subset of these disorders leading to susceptibility to infections and autoimmunity. Infections in DNA repair defects may occur due to primary defects in T, B, or NK cells and other factors such as anatomic defects, neurologic disorders, or during chemotherapy. Consequently, the characteristics of the infections may vary from mild upper respiratory tract infections to severe, opportunistic, and even fatal infections with bacteria, viruses, or fungi. Here, infections in 15 rare and sporadic DNA repair defects that are associated with immunodeficiencies are discussed. Because of the rarity of some of these conditions, limited information is available regarding infectious complications. MDPI 2023-03-10 /pmc/articles/PMC10054915/ /pubmed/36986362 http://dx.doi.org/10.3390/pathogens12030440 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yilmaz Demirdag, Yesim
Gupta, Sudhir
Infections in DNA Repair Defects
title Infections in DNA Repair Defects
title_full Infections in DNA Repair Defects
title_fullStr Infections in DNA Repair Defects
title_full_unstemmed Infections in DNA Repair Defects
title_short Infections in DNA Repair Defects
title_sort infections in dna repair defects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054915/
https://www.ncbi.nlm.nih.gov/pubmed/36986362
http://dx.doi.org/10.3390/pathogens12030440
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