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Infections in DNA Repair Defects
DNA repair defects are heterogenous conditions characterized by a wide spectrum of clinical phenotypes. The common presentations of DNA repair defects include increased risk of cancer, accelerated aging, and defects in the development of various organs and systems. The immune system can be affected...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054915/ https://www.ncbi.nlm.nih.gov/pubmed/36986362 http://dx.doi.org/10.3390/pathogens12030440 |
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author | Yilmaz Demirdag, Yesim Gupta, Sudhir |
author_facet | Yilmaz Demirdag, Yesim Gupta, Sudhir |
author_sort | Yilmaz Demirdag, Yesim |
collection | PubMed |
description | DNA repair defects are heterogenous conditions characterized by a wide spectrum of clinical phenotypes. The common presentations of DNA repair defects include increased risk of cancer, accelerated aging, and defects in the development of various organs and systems. The immune system can be affected in a subset of these disorders leading to susceptibility to infections and autoimmunity. Infections in DNA repair defects may occur due to primary defects in T, B, or NK cells and other factors such as anatomic defects, neurologic disorders, or during chemotherapy. Consequently, the characteristics of the infections may vary from mild upper respiratory tract infections to severe, opportunistic, and even fatal infections with bacteria, viruses, or fungi. Here, infections in 15 rare and sporadic DNA repair defects that are associated with immunodeficiencies are discussed. Because of the rarity of some of these conditions, limited information is available regarding infectious complications. |
format | Online Article Text |
id | pubmed-10054915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100549152023-03-30 Infections in DNA Repair Defects Yilmaz Demirdag, Yesim Gupta, Sudhir Pathogens Review DNA repair defects are heterogenous conditions characterized by a wide spectrum of clinical phenotypes. The common presentations of DNA repair defects include increased risk of cancer, accelerated aging, and defects in the development of various organs and systems. The immune system can be affected in a subset of these disorders leading to susceptibility to infections and autoimmunity. Infections in DNA repair defects may occur due to primary defects in T, B, or NK cells and other factors such as anatomic defects, neurologic disorders, or during chemotherapy. Consequently, the characteristics of the infections may vary from mild upper respiratory tract infections to severe, opportunistic, and even fatal infections with bacteria, viruses, or fungi. Here, infections in 15 rare and sporadic DNA repair defects that are associated with immunodeficiencies are discussed. Because of the rarity of some of these conditions, limited information is available regarding infectious complications. MDPI 2023-03-10 /pmc/articles/PMC10054915/ /pubmed/36986362 http://dx.doi.org/10.3390/pathogens12030440 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yilmaz Demirdag, Yesim Gupta, Sudhir Infections in DNA Repair Defects |
title | Infections in DNA Repair Defects |
title_full | Infections in DNA Repair Defects |
title_fullStr | Infections in DNA Repair Defects |
title_full_unstemmed | Infections in DNA Repair Defects |
title_short | Infections in DNA Repair Defects |
title_sort | infections in dna repair defects |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054915/ https://www.ncbi.nlm.nih.gov/pubmed/36986362 http://dx.doi.org/10.3390/pathogens12030440 |
work_keys_str_mv | AT yilmazdemirdagyesim infectionsindnarepairdefects AT guptasudhir infectionsindnarepairdefects |