GITR and TIGIT immunotherapy provokes divergent multi-cellular responses in the tumor microenvironment of gastrointestinal cancers

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Understanding the cellular mechanisms of novel immunotherapy agents in the human tumor microenvironment (TME) is critical to their clinical success. We examined GITR and TIGIT immunotherapy in gastric and colon cancer patients using ex vivo slice tumor slice cultures derived from cancer surgical res...

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Detalles Bibliográficos
Autores principales: Sathe, Anuja, Ayala, Carlos, Bai, Xiangqi, Grimes, Susan M., Lee, Byrne, Kin, Cindy, Shelton, Andrew, Poultsides, George, Ji, Hanlee P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054933/
https://www.ncbi.nlm.nih.gov/pubmed/36993756
http://dx.doi.org/10.1101/2023.03.13.532299
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