Dimensionality reduction methods for extracting functional networks from large-scale CRISPR screens

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CRISPR-Cas9 screens facilitate the discovery of gene functional relationships and phenotype-specific dependencies. The Cancer Dependency Map (DepMap) is the largest compendium of whole-genome CRISPR screens aimed at identifying cancer-specific genetic dependencies across human cell lines. A mitochon...

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Detalles Bibliográficos
Autores principales: Zernab Hassan, Arshia, Ward, Henry N., Rahman, Mahfuzur, Billmann, Maximilian, Lee, Yoonkyu, Myers, Chad L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054965/
https://www.ncbi.nlm.nih.gov/pubmed/36993440
http://dx.doi.org/10.1101/2023.02.22.529573
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