Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops

Lineage-defining transcription factors form densely interconnected circuits in chromatin occupancy assays, but the functional significance of these networks remains underexplored. We reconstructed the functional topology of a leukemia cell transcription network from the direct gene-regulatory progra...

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Detalles Bibliográficos
Autores principales: Harada, Taku, Kalfon, Jérémie, Perez, Monika W., Eagle, Kenneth, Braes, Flora Dievenich, Batley, Rashad, Heshmati, Yaser, Ferrucio, Juliana Xavier, Ewers, Jazmin, Mehta, Stuti, Kossenkov, Andrew, Ellegast, Jana M., Bowker, Allyson, Wickramasinghe, Jayamanna, Nabet, Behnam, Paralkar, Vikram R., Dharia, Neekesh V., Stegmaier, Kimberly, Orkin, Stuart H., Pimkin, Maxim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054969/
https://www.ncbi.nlm.nih.gov/pubmed/36993171
http://dx.doi.org/10.1101/2023.03.13.532438

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