Nanobodies against SARS-CoV-2 reduced virus load in the brain of challenged mice and neutralized Wuhan, Delta and Omicron Variants

In this work, we developed llama-derived nanobodies (Nbs) directed to the receptor binding domain (RBD) and other domains of the Spike (S) protein of SARS-CoV-2. Nanobodies were selected after the biopanning of two VHH-libraries, one of which was generated after the immunization of a llama (lama gla...

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Detalles Bibliográficos
Autores principales: Pavan, María Florencia, Bok, Marina, Juan, Rafael Betanzos San, Malito, Juan Pablo, Marcoppido, Gisela Ariana, Franco, Diego Rafael, Militello, Daniela Ayelen, Schammas, Juan Manuel, Bari, Sara, Stone, William B., López, Krisangel, Porier, Danielle L., Muller, John, Auguste, Albert J., Yuan, Lijuan, Wigdorovitz, Andrés, Parreño, Viviana, Ibañez, Lorena Itatí
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054972/
https://www.ncbi.nlm.nih.gov/pubmed/36993215
http://dx.doi.org/10.1101/2023.03.14.532528

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