Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP

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Phase separation is a ubiquitous process that compartmentalizes many cellular pathways. Given that the same interactions that drive phase separation mediate the formation of complexes below the saturation concentration, the contribution of condensates vs complexes to function is not always clear. He...

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Detalles Bibliográficos
Autores principales: Sabri, Nafiseh, Cuneo, Matthew J., Marzahn, Melissa R., Lee, Jihun, Bouchard, Jill J., Vaithiyalingam, Sivaraja, Borgia, Madeleine B., Schmit, Jeremy, Mittag, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054981/
https://www.ncbi.nlm.nih.gov/pubmed/36993550
http://dx.doi.org/10.1101/2023.02.11.528154

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