Cargando…

Rational Coformer Selection in the Development of 6-Propyl-2-thiouracil Pharmaceutical Cocrystals

Pharmaceutical multicomponent solids have proved to efficiently modulate the physicochemical properties of active pharmaceutical ingredients. In this context, polyphenols are interesting coformers for designing pharmaceutical cocrystals due to their wide safety profile and interesting antioxidant pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Acebedo-Martínez, Francisco Javier, Alarcón-Payer, Carolina, Verdugo-Escamilla, Cristóbal, Martín, Jesús, Frontera, Antonio, Domínguez-Martín, Alicia, Gómez-Morales, Jaime, Choquesillo-Lazarte, Duane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055029/ https://www.ncbi.nlm.nih.gov/pubmed/36986470 http://dx.doi.org/10.3390/ph16030370

Ejemplares similares

Novel Polymorphic Cocrystals of the Non-Steroidal Anti-Inflammatory Drug Niflumic Acid: Expanding the Pharmaceutical Landscape
por: Acebedo-Martínez, Francisco Javier, et al.
Publicado: (2021)

Metformin-NSAIDs Molecular Salts: A Path towards Enhanced Oral Bioavailability and Stability
por: Acebedo-Martínez, Francisco Javier, et al.
Publicado: (2023)

Enhanced NSAIDs Solubility in Drug–Drug Formulations with Ciprofloxacin †
por: Acebedo-Martínez, Francisco Javier, et al.
Publicado: (2023)

Cocrystals by Design: A Rational Coformer Selection Approach for Tackling the API Problems
por: Singh, Maan, et al.
Publicado: (2023)

Application of 1-Hydroxy-4,5-Dimethyl-Imidazole 3-Oxide as Coformer in Formation of Pharmaceutical Cocrystals
por: Wróblewska, Aneta, et al.
Publicado: (2020)

Searching for Suitable Kojic Acid Coformers: From Cocrystals and Salt to Eutectics
por: Sun, Renren, et al.
Publicado: (2023)

Thermal assisted self-organization of calcium carbonate
por: Zhang, Gan, et al.
Publicado: (2018)

New Lidocaine-Based Pharmaceutical Cocrystals: Preparation, Characterization, and Influence of the Racemic vs. Enantiopure Coformer on the Physico-Chemical Properties
por: Ma, Panpan, et al.
Publicado: (2023)

Crystal Structure, Solubility, and Pharmacokinetic Study on a Hesperetin Cocrystal with Piperine as Coformer
por: Liu, Yanjie, et al.
Publicado: (2022)

Supramolecular Sandwiches: Halogen-Bonded Coformers Direct [2+2] Photoreactivity in Two-Component Cocrystals
por: Quentin, Jay, et al.
Publicado: (2020)

Novel Purine Alkaloid Cocrystals with Trimesic and Hemimellitic Acids as Coformers: Synthetic Approach and Supramolecular Analysis
por: Gołdyn, M. R., et al.
Publicado: (2020)

Efficient Screening of Coformers for Active Pharmaceutical Ingredient Cocrystallization
por: Sugden, Isaac J., et al.
Publicado: (2022)

The effects of pH, surfactant, ion concentration, coformer, and molecular arrangement on the solubility behavior of myricetin cocrystals
por: Ren, Shuzhen, et al.
Publicado: (2019)

Luminescent Citrate-Functionalized Terbium-Substituted Carbonated Apatite Nanomaterials: Structural Aspects, Sensitized Luminescence, Cytocompatibility, and Cell Uptake Imaging
por: Gómez-Morales, Jaime, et al.
Publicado: (2022)

Critical Analysis and Optimization of Stoichiometric Ratio of Drug-Coformer on Cocrystal Design: Molecular Docking, In Vitro and In Vivo Assessment
por: Dhibar, Manami, et al.
Publicado: (2023)

Crystallization, Luminescence and Cytocompatibility of Hexagonal Calcium Doped Terbium Phosphate Hydrate Nanoparticles
por: Gómez-Morales, Jaime, et al.
Publicado: (2021)

Pharmaceutical Cocrystals and Their Physicochemical Properties
por: Schultheiss, Nate, et al.
Publicado: (2009)

Thyroidectomy or Thiouracil?
por: Short, A. Rendle
Publicado: (1948)

Thiouracil in Thyrotoxicosis
Publicado: (1948)

Recent Advances in Pharmaceutical Cocrystals: A Focused Review of Flavonoid Cocrystals
por: Xu, Jia, et al.
Publicado: (2023)

Urea as a Cocrystal Former—Study of 3 Urea Based Pharmaceutical Cocrystals
por: Leng, Fucheng, et al.
Publicado: (2021)

Thiouracil in the Treatment of Thyrotoxicosis
por: Dunlop, D. M.
Publicado: (1945)

The Copper(II)-Thiodiacetate (tda) Chelate as Efficient Receptor of N9-(2-Hydroxyethyl)Adenine (9heade): Synthesis, Molecular and Crystal Structures, Physical Properties and DFT Calculations of [Cu(tda)(9heade)(H(2)O)]·2H(2)O
por: Rosales-Martínez, Carmen, et al.
Publicado: (2023)

A Review of Coformer Utilization in Multicomponent Crystal Formation
por: Wathoni, Nasrul, et al.
Publicado: (2022)

trans-Diaquabis(l-phenylalaninato-κ(2) N,O)nickel(II)
por: Ghorbanloo, Massomeh, et al.
Publicado: (2012)

Pharmaceutical Cocrystal of Piroxicam: Design, Formulation and Evaluation
por: Panzade, Prabhakar, et al.
Publicado: (2017)

Dicopper(II)-EDTA Chelate as a Bicephalic Receptor Model for a Synthetic Adenine Nucleoside
por: García-Rubiño, María Eugenia, et al.
Publicado: (2021)

The Treatment of Toxic Goitre with Thiouracil
por: Kennie, Agnes T.
Publicado: (1945)

Thiouracil and Methylthiouracil in Treatment of Thyrotoxicosis
por: Eaton, James Caithness
Publicado: (1947)

5-Phenyl-3-(2-phosphonoethyl)-1,2,3-triazol-1-ium chloride
por: Chachlaki, Elpiniki, et al.
Publicado: (2022)

catena-Poly[oxidanium [tris{μ-[amino(iminio)methyl]phosphonato}zincate(II)]]
por: Chachlaki, Elpiniki, et al.
Publicado: (2022)

Differences in Coformer Interactions of the 2,4-Diaminopyrimidines Pyrimethamine and Trimethoprim
por: Alaa Eldin Refat, Lamis, et al.
Publicado: (2022)

H(N3)dap (Hdap = 2,6-Diaminopurine) Recognition by Cu(2)(EGTA): Structure, Physical Properties, and Density Functional Theory Calculations of [Cu(4)(μ-EGTA)(2)(μ-H(N3)dap)(2)(H(2)O)(2)]·7H(2)O
por: Mousavi, Homa, et al.
Publicado: (2023)

Recent Advances in Pharmaceutical Cocrystals: From Bench to Market
por: Kumar Bandaru, Ravi, et al.
Publicado: (2021)

Obtaining Cocrystals by Reaction Crystallization Method: Pharmaceutical Applications
por: Biscaia, Isabela Fanelli Barreto, et al.
Publicado: (2021)

Mechanochemistry: A Green Approach in the Preparation of Pharmaceutical Cocrystals
por: Solares-Briones, Mizraín, et al.
Publicado: (2021)

Pharmaceutical cocrystal of antibiotic drugs: A comprehensive review
por: Bashimam, Mais, et al.
Publicado: (2022)

Uracil Derivatives for Halogen-Bonded Cocrystals
por: Benito, Mónica, et al.
Publicado: (2021)

Pharmacokinetics in melanoma-bearing mice of 5-dihydroxyboryl-6-propyl-2-thiouracil (BPTU), a candidate compound for boron neutron capture therapy.
por: Verrijk, R., et al.
Publicado: (1994)

Hydration Energies of Protonated and Sodiated Thiouracils
por: Wincel, Henryk
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_3pbph2e881i5sjqcokquvgs57c