Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice

Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity, where every olfactory neuron expresses one out of ~2000 OR alleles in a probabilistic, yet stereotypic fashion. Here, we propose that topographic restrictions in OR expression are established in neuronal pro...

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Detalles Bibliográficos
Autores principales: Bashkirova, Elizaveta V., Klimpert, Nell, Monahan, Kevin, Campbell, Christine E., Osinski, Jason M., Tan, Longzhi, Schieren, Ira, Pourmorady, Ariel, Stecky, Beka, Barnea, Gilad, Xie, X. Sunnie, Abdus-Saboor, Ishmail, Shykind, Benjamin, Jones-Marlin, Bianca, Gronostajski, Richard M., Fleischmann, Alexander, Lomvardas, Stavros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055043/
https://www.ncbi.nlm.nih.gov/pubmed/36993168
http://dx.doi.org/10.1101/2023.03.15.532726

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