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Frequency-dependent ecological interactions increase the prevalence, and shape the distribution, of pre-existing drug resistance
The evolution of resistance remains one of the primary challenges for modern medicine from infectious diseases to cancers. Many of these resistance-conferring mutations often carry a substantial fitness cost in the absence of treatment. As a result, we would expect these mutants to undergo purifying...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055114/ https://www.ncbi.nlm.nih.gov/pubmed/36993678 http://dx.doi.org/10.1101/2023.03.16.533001 |