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A general computational design strategy for stabilizing viral class I fusion proteins

Many pathogenic viruses, including influenza virus, Ebola virus, coronaviruses, and Pneumoviruses, rely on class I fusion proteins to fuse viral and cellular membranes. To drive the fusion process, class I fusion proteins undergo an irreversible conformational change from a metastable prefusion stat...

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Detalles Bibliográficos
Autores principales:	Gonzalez, Karen J., Huang, Jiachen, Criado, Miria F., Banerjee, Avik, Tompkins, Stephen, Mousa, Jarrod J., Strauch, Eva-Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055117/ https://www.ncbi.nlm.nih.gov/pubmed/36993551 http://dx.doi.org/10.1101/2023.03.16.532924

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