DnaJC7 specifically regulates tau seeding

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Neurodegenerative tauopathies are caused by accumulation of toxic tau protein assemblies. This appears to involve template-based seeding events, whereby tau monomer changes conformation and is recruited to a growing aggregate. Several large families of chaperone proteins, including Hsp70s and J doma...

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Detalles Bibliográficos
Autores principales: Perez, Valerie A., Sanders, David W., Mendoza-Oliva, Ayde, Stopschinski, Barbara E., Mullapudi, Vishruth, White, Charles L, Joachimiak, Lukasz A., Diamond, Marc I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055123/
https://www.ncbi.nlm.nih.gov/pubmed/36993367
http://dx.doi.org/10.1101/2023.03.16.532880
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