Cargando…
Single-shot 3D photoacoustic tomography using a single-element detector for ultrafast imaging of hemodynamics
Imaging hemodynamics is crucial for the diagnosis, treatment, and prevention of vascular diseases. However, current imaging techniques are limited due to the use of ionizing radiation or contrast agents, short penetration depth, or complex and expensive data acquisition systems. Photoacoustic tomogr...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055152/ https://www.ncbi.nlm.nih.gov/pubmed/36993341 http://dx.doi.org/10.1101/2023.03.14.532661 |
_version_ | 1785015830639017984 |
---|---|
author | Zhang, Yide Hu, Peng Li, Lei Cao, Rui Khadria, Anjul Maslov, Konstantin Tong, Xin Zeng, Yushun Jiang, Laiming Zhou, Qifa Wang, Lihong V. |
author_facet | Zhang, Yide Hu, Peng Li, Lei Cao, Rui Khadria, Anjul Maslov, Konstantin Tong, Xin Zeng, Yushun Jiang, Laiming Zhou, Qifa Wang, Lihong V. |
author_sort | Zhang, Yide |
collection | PubMed |
description | Imaging hemodynamics is crucial for the diagnosis, treatment, and prevention of vascular diseases. However, current imaging techniques are limited due to the use of ionizing radiation or contrast agents, short penetration depth, or complex and expensive data acquisition systems. Photoacoustic tomography shows promise as a solution to these issues. However, existing photoacoustic tomography methods collect signals either sequentially or through numerous detector elements, leading to either low imaging speed or high system complexity and cost. To address these issues, here we introduce a method to capture a 3D photoacoustic image of vasculature using a single laser pulse and a single-element detector that functions as 6,400 virtual ones. Our method enables ultrafast volumetric imaging of hemodynamics in the human body at up to 1 kHz and requires only a single calibration for different objects and for long-term operations. We demonstrate 3D imaging of hemodynamics at depth in humans and small animals, capturing the variability in blood flow speeds. This concept can inspire other imaging technologies and find applications such as home-care monitoring, biometrics, point-of-care testing, and wearable monitoring. |
format | Online Article Text |
id | pubmed-10055152 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-100551522023-03-30 Single-shot 3D photoacoustic tomography using a single-element detector for ultrafast imaging of hemodynamics Zhang, Yide Hu, Peng Li, Lei Cao, Rui Khadria, Anjul Maslov, Konstantin Tong, Xin Zeng, Yushun Jiang, Laiming Zhou, Qifa Wang, Lihong V. bioRxiv Article Imaging hemodynamics is crucial for the diagnosis, treatment, and prevention of vascular diseases. However, current imaging techniques are limited due to the use of ionizing radiation or contrast agents, short penetration depth, or complex and expensive data acquisition systems. Photoacoustic tomography shows promise as a solution to these issues. However, existing photoacoustic tomography methods collect signals either sequentially or through numerous detector elements, leading to either low imaging speed or high system complexity and cost. To address these issues, here we introduce a method to capture a 3D photoacoustic image of vasculature using a single laser pulse and a single-element detector that functions as 6,400 virtual ones. Our method enables ultrafast volumetric imaging of hemodynamics in the human body at up to 1 kHz and requires only a single calibration for different objects and for long-term operations. We demonstrate 3D imaging of hemodynamics at depth in humans and small animals, capturing the variability in blood flow speeds. This concept can inspire other imaging technologies and find applications such as home-care monitoring, biometrics, point-of-care testing, and wearable monitoring. Cold Spring Harbor Laboratory 2023-03-15 /pmc/articles/PMC10055152/ /pubmed/36993341 http://dx.doi.org/10.1101/2023.03.14.532661 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Zhang, Yide Hu, Peng Li, Lei Cao, Rui Khadria, Anjul Maslov, Konstantin Tong, Xin Zeng, Yushun Jiang, Laiming Zhou, Qifa Wang, Lihong V. Single-shot 3D photoacoustic tomography using a single-element detector for ultrafast imaging of hemodynamics |
title | Single-shot 3D photoacoustic tomography using a single-element detector for ultrafast imaging of hemodynamics |
title_full | Single-shot 3D photoacoustic tomography using a single-element detector for ultrafast imaging of hemodynamics |
title_fullStr | Single-shot 3D photoacoustic tomography using a single-element detector for ultrafast imaging of hemodynamics |
title_full_unstemmed | Single-shot 3D photoacoustic tomography using a single-element detector for ultrafast imaging of hemodynamics |
title_short | Single-shot 3D photoacoustic tomography using a single-element detector for ultrafast imaging of hemodynamics |
title_sort | single-shot 3d photoacoustic tomography using a single-element detector for ultrafast imaging of hemodynamics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055152/ https://www.ncbi.nlm.nih.gov/pubmed/36993341 http://dx.doi.org/10.1101/2023.03.14.532661 |
work_keys_str_mv | AT zhangyide singleshot3dphotoacoustictomographyusingasingleelementdetectorforultrafastimagingofhemodynamics AT hupeng singleshot3dphotoacoustictomographyusingasingleelementdetectorforultrafastimagingofhemodynamics AT lilei singleshot3dphotoacoustictomographyusingasingleelementdetectorforultrafastimagingofhemodynamics AT caorui singleshot3dphotoacoustictomographyusingasingleelementdetectorforultrafastimagingofhemodynamics AT khadriaanjul singleshot3dphotoacoustictomographyusingasingleelementdetectorforultrafastimagingofhemodynamics AT maslovkonstantin singleshot3dphotoacoustictomographyusingasingleelementdetectorforultrafastimagingofhemodynamics AT tongxin singleshot3dphotoacoustictomographyusingasingleelementdetectorforultrafastimagingofhemodynamics AT zengyushun singleshot3dphotoacoustictomographyusingasingleelementdetectorforultrafastimagingofhemodynamics AT jianglaiming singleshot3dphotoacoustictomographyusingasingleelementdetectorforultrafastimagingofhemodynamics AT zhouqifa singleshot3dphotoacoustictomographyusingasingleelementdetectorforultrafastimagingofhemodynamics AT wanglihongv singleshot3dphotoacoustictomographyusingasingleelementdetectorforultrafastimagingofhemodynamics |