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Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade

The mitochondrial genome encodes essential machinery for respiration and metabolic homeostasis but is paradoxically among the most common targets of somatic mutation in the cancer genome, with truncating mutations in respiratory complex I genes being most over-represented(1). While mitochondrial DNA...

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Detalles Bibliográficos
Autores principales:	Mahmood, Mahnoor, Liu, Eric Minwei, Shergold, Amy L., Tolla, Elisabetta, Tait-Mulder, Jacqueline, Huerta Uribe, Alejandro, Shokry, Engy, Young, Alex L., Lilla, Sergio, Kim, Minsoo, Park, Tricia, Manchon, J.L., Rodríguez-Antona, Crístina, Walters, Rowan C., Springett, Roger J., Blaza, James N., Zanivan, Sara, Sumpton, David, Roberts, Edward W., Reznik, Ed, Gammage, Payam A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055208/ https://www.ncbi.nlm.nih.gov/pubmed/36993533 http://dx.doi.org/10.1101/2023.03.21.533091

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