Two sequence- and two structure-based ML models have learned different aspects of protein biochemistry

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Deep learning models are seeing increased use as methods to predict mutational effects or allowed mutations in proteins. The models commonly used for these purposes include large language models (LLMs) and 3D Convolutional Neural Networks (CNNs). These two model types have very different architectur...

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Detalles Bibliográficos
Autores principales: Kulikova, Anastasiya V., Diaz, Daniel J., Chen, Tianlong, Jeffrey Cole, T., Ellington, Andrew D., Wilke, Claus O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055221/
https://www.ncbi.nlm.nih.gov/pubmed/36993648
http://dx.doi.org/10.1101/2023.03.20.533508
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