Mechanistic and structural insights into a divergent PLP-dependent L-enduracididine cyclase from a toxic cyanobacterium

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Cyclic arginine noncanonical amino acids (ncAAs) are found in several actinobacterial peptide natural products with therapeutically useful antibacterial properties. The preparation of ncAAs like enduracididine and capreomycidine currently takes multiple biosynthetic or chemosynthetic steps, thus lim...

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Detalles Bibliográficos
Autores principales: Cordoza, Jennifer L., Chen, Percival Yang-Ting, Blaustein, Linnea R., Lima, Stella T., Fiore, Marli F., Chekan, Jonathan R., Moore, Bradley S., McKinnie, Shaun M. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055224/
https://www.ncbi.nlm.nih.gov/pubmed/36993528
http://dx.doi.org/10.1101/2023.03.21.533663
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