Cryo-EM structure of the human Sirtuin 6-nucleosome complex

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Sirtuin 6 (SIRT6) is a multifaceted protein deacetylase/deacylase and a major target for small-molecule modulators of longevity and cancer. In the context of chromatin, SIRT6 removes acetyl groups from histone H3 in nucleosomes, but the molecular basis for its nucleosomal substrate preference is unk...

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Detalles Bibliográficos
Autores principales: Chio, Un Seng, Rechiche, Othman, Bryll, Alysia R., Zhu, Jiang, Feldman, Jessica L., Peterson, Craig L., Tan, Song, Armache, Jean-Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055229/
https://www.ncbi.nlm.nih.gov/pubmed/36993468
http://dx.doi.org/10.1101/2023.03.17.533206
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