ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer’s disease

ZCCHC17 is a putative master regulator of synaptic gene dysfunction in Alzheimer’s Disease (AD), and ZCCHC17 protein declines early in AD brain tissue, before significant gliosis or neuronal loss. Here, we investigate the function of ZCCHC17 and its role in AD pathogenesis. Co-immunoprecipitation of...

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Detalles Bibliográficos
Autores principales: Bartosch, Anne Marie W., Youth, Elliot H. H., Hansen, Shania, Kaufman, Maria E., Xiao, Harrison, Koo, So Yeon, Ashok, Archana, Sivakumar, Sharanya, Soni, Rajesh K., Dumitrescu, Logan C., Lam, Tiffany G., Ropri, Ali S., Lee, Annie J., Klein, Hans-Ulrich, Vardarajan, Badri N., Bennett, David A., Young-Pearse, Tracy L., De Jager, Philip L., Hohman, Timothy J., Sproul, Andrew A., Teich, Andrew F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055234/
https://www.ncbi.nlm.nih.gov/pubmed/36993746
http://dx.doi.org/10.1101/2023.03.21.533654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055234/
https://www.ncbi.nlm.nih.gov/pubmed/36993746
http://dx.doi.org/10.1101/2023.03.21.533654

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