Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal

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A long-standing goal of amyloid research has been to characterize the structural basis of the rate-determining nucleating event. However, the ephemeral nature of nucleation has made this goal unachievable with existing biochemistry, structural biology, and computational approaches. Here, we addresse...

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Detalles Bibliográficos
Autores principales: Kandola, Tej, Venkatesan, Shriram, Zhang, Jiahui, Lerbakken, Brooklyn, Schulze, Alex Von, Blanck, Jillian F, Wu, Jianzheng, Unruh, Jay, Berry, Paula, Lange, Jeffrey J., Box, Andrew, Cook, Malcolm, Sagui, Celeste, Halfmann, Randal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055281/
https://www.ncbi.nlm.nih.gov/pubmed/36993401
http://dx.doi.org/10.1101/2023.03.20.533418
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