Reduction of Spermine Synthase Suppresses Tau Accumulation Through Autophagy Modulation in Tauopathy

Tauopathy, including Alzheimer Disease (AD), is characterized by Tau protein accumulation and autophagy dysregulation. Emerging evidence connects polyamine metabolism with the autophagy pathway, however the role of polyamines in Tauopathy remains unclear. In the present study we investigated the rol...

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Detalles Bibliográficos
Autores principales: Tao, Xianzun, Liu, Jiaqi, Diaz-Perez, Zoraida, Foley, Jackson R, Stewart, Tracy Murray, Casero, Robert A, Zhai, R. Grace
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055309/
https://www.ncbi.nlm.nih.gov/pubmed/36993333
http://dx.doi.org/10.1101/2023.03.17.533015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055309/
https://www.ncbi.nlm.nih.gov/pubmed/36993333
http://dx.doi.org/10.1101/2023.03.17.533015

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